Explore TPO gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
| Target ID |
GM-T51120
|
| Target Name |
TPO
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7173
|
| Gene ID |
100072955 (Equus caballus), 101098706 (Felis catus), 22018 (Mus musculus), 403521 (Canis lupus familiaris)
525013 (Bos taurus), 54314 (Rattus norvegicus), 7173 (Homo sapiens), 721610 (Macaca mulatta)
|
| Target Alternative Names |
MSA,TDH2A,TPO,TPX,Thyroid peroxidase,Tpo
|
| Uniprot Accession |
P35419,Q8HYB7,P14650,P07202
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Diagnostics Biomarker
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Thyroid hormone synthesis, Autoimmune thyroid disease
|
| Gene Ensembl |
ENSECAG00000025046, ENSMUSG00000020673, ENSCAFG00845017327, ENSBTAG00000055050, ENSG00000115705, ENSMMUG00000009662
|
Pre-made viral vector of TPO cDNA Clones/ORF Plasmid
TPO siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7173 | Pre-made Human TPO/MSA/TPX siRNA oligo Duplex | 7173 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54314 | Pre-made Rat Tpo siRNA oligo Duplex | 54314 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22018 | Pre-made Mouse Tpo siRNA oligo Duplex | 22018 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo721610 | Pre-made Cynomolgus/Rhesus macaque TPO siRNA oligo Duplex | 721610 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098706 | Pre-made Cat/Feline TPO siRNA oligo Duplex | 101098706 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403521 | Pre-made Dog/Canine TPO siRNA oligo Duplex | 403521 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo525013 | Pre-made Bovines/Cattle TPO siRNA oligo Duplex | 525013 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072955 | Pre-made Equine/Horse TPO siRNA oligo Duplex | 100072955 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TPO antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51120-Ab | Human | Anti-Human TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T51120-Ab | Rat | Anti-Rat TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T51120-Ab | Mouse | Anti-Mouse TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T51120-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T51120-Ab | Cat/Feline | Anti-Cat/Feline TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T51120-Ab | Dog/Canine | Anti-Dog/Canine TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T51120-Ab | Bovines/Cattle | Anti-Bovines/Cattle TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T51120-Ab | Equine/Horse | Anti-Equine/Horse TPO monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
TPO VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51120-Ag | Human | Human TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T51120-Ag | Rat | Rat TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T51120-Ag | Mouse | Mouse TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T51120-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T51120-Ag | Cat/Feline | Cat/Feline TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T51120-Ag | Dog/Canine | Dog/Canine TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T51120-Ag | Bovines/Cattle | Bovines/Cattle TPO VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T51120-Ag | Equine/Horse | Equine/Horse TPO VLP (virus-like particle) | HEK293 | Products Developing |
