Explore L-VOCC/CACNA1C gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
| Target ID |
GM-T51115
|
| Target Name |
L-VOCC/CACNA1C
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
775
|
| Gene ID |
100049924 (Equus caballus), 101082923 (Felis catus), 12288 (Mus musculus), 24239 (Rattus norvegicus)
403516 (Canis lupus familiaris), 408015 (Bos taurus), 721721 (Macaca mulatta), 775 (Homo sapiens)
|
| Target Alternative Names |
CACH2,CACN2,CACNA1C,CACNA1C-IT2,CACNL1A1,CAV1.2,CCHL1A1,CaV1.2,Cacna1c,Calcium channel,Cav1.2,Cchl1a1,D930026N18Rik,ICA,L type,L-VOCC,LQT8,MBC,MELC-CC,NEDHLSS,RATIVS302,TS,TS. LQT8,Voltage-dependent L-type calcium channel subunit alpha-1C,Voltage-gated calcium channel subunit alpha Cav1.2,alpha-1 polypeptide,cardiac muscle,isoform 1
|
| Uniprot Accession |
Q01815,P22002,Q13936
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000019096, ENSMUSG00000051331, ENSCAFG00845030375, ENSBTAG00000010660, ENSMMUG00000012988, ENSG00000151067
|
| Target Classification |
Ion Channel
|
L-VOCC/CACNA1C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo775 | Pre-made Human CACNA1C/TS/LQT8 siRNA oligo Duplex | 775 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24239 | Pre-made Rat Cacna1c/RATIVS302 siRNA oligo Duplex | 24239 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12288 | Pre-made Mouse Cacna1c/MBC/Cav1.2 siRNA oligo Duplex | 12288 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo721721 | Pre-made Cynomolgus/Rhesus macaque CACNA1C siRNA oligo Duplex | 721721 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082923 | Pre-made Cat/Feline CACNA1C siRNA oligo Duplex | 101082923 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403516 | Pre-made Dog/Canine CACNA1C/ICA siRNA oligo Duplex | 403516 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo408015 | Pre-made Bovines/Cattle CACNA1C/CAV1.2 siRNA oligo Duplex | 408015 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100049924 | Pre-made Equine/Horse CACNA1C siRNA oligo Duplex | 100049924 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
L-VOCC/CACNA1C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51115-Ab | Human | Anti-Human L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T51115-Ab | Rat | Anti-Rat L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T51115-Ab | Mouse | Anti-Mouse L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T51115-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T51115-Ab | Cat/Feline | Anti-Cat/Feline L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T51115-Ab | Dog/Canine | Anti-Dog/Canine L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T51115-Ab | Bovines/Cattle | Anti-Bovines/Cattle L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T51115-Ab | Equine/Horse | Anti-Equine/Horse L-VOCC/CACNA1C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
L-VOCC/CACNA1C VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51115-Ag | Human | Human L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T51115-Ag | Rat | Rat L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T51115-Ag | Mouse | Mouse L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T51115-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T51115-Ag | Cat/Feline | Cat/Feline L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T51115-Ag | Dog/Canine | Dog/Canine L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T51115-Ag | Bovines/Cattle | Bovines/Cattle L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T51115-Ag | Equine/Horse | Equine/Horse L-VOCC/CACNA1C VLP (virus-like particle) | HEK293 | Products Developing |
