Explore TrkC/NTRK3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
| Target ID |
GM-T51076
|
| Target Name |
TrkC/NTRK3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4916
|
| Gene ID |
100069852 (Equus caballus), 100856261 (Canis lupus familiaris), 101085548 (Felis catus), 18213 (Mus musculus)
29613 (Rattus norvegicus), 4916 (Homo sapiens), 539126 (Bos taurus), 697615 (Macaca mulatta)
|
| Target Alternative Names |
GP145-TrkC,GP145-TrkC (Trk-C),NT-3 growth factor receptor,NTRK3,Neurotrophic tyrosine kinase receptor type 3,Ntrk3,Ntrk3_tv3,TRKC,TrkC,TrkC tyrosine kinase,gp145(trkC),trkC
|
| Uniprot Accession |
Q6VNS1,Q03351,Q16288
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Calcium signaling pathway, Neurotrophin signaling pathway, Central carbon metabolism in cancer
|
| Gene Ensembl |
ENSECAG00000012510, ENSCAFG00845003493, ENSMUSG00000059146, ENSG00000140538, ENSBTAG00000047543, ENSMMUG00000001386
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of TrkC/NTRK3 cDNA Clones/ORF Plasmid
TrkC/NTRK3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4916 | Pre-made Human NTRK3/TRKC/GP145-TrkC siRNA oligo Duplex | 4916 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29613 | Pre-made Rat Ntrk3/trkC siRNA oligo Duplex | 29613 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18213 | Pre-made Mouse Ntrk3/TrkC/Ntrk3_tv3 siRNA oligo Duplex | 18213 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697615 | Pre-made Cynomolgus/Rhesus macaque NTRK3 siRNA oligo Duplex | 697615 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085548 | Pre-made Cat/Feline NTRK3 siRNA oligo Duplex | 101085548 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856261 | Pre-made Dog/Canine NTRK3 siRNA oligo Duplex | 100856261 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539126 | Pre-made Bovines/Cattle NTRK3 siRNA oligo Duplex | 539126 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069852 | Pre-made Equine/Horse NTRK3 siRNA oligo Duplex | 100069852 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TrkC/NTRK3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51076-Ab | Human | Anti-Human TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T51076-Ab | Rat | Anti-Rat TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T51076-Ab | Mouse | Anti-Mouse TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T51076-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T51076-Ab | Cat/Feline | Anti-Cat/Feline TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T51076-Ab | Dog/Canine | Anti-Dog/Canine TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T51076-Ab | Bovines/Cattle | Anti-Bovines/Cattle TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T51076-Ab | Equine/Horse | Anti-Equine/Horse TrkC/NTRK3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TrkC/NTRK3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51076-Ag | Human | Human TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T51076-Ag | Rat | Rat TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T51076-Ag | Mouse | Mouse TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T51076-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T51076-Ag | Cat/Feline | Cat/Feline TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T51076-Ag | Dog/Canine | Dog/Canine TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T51076-Ag | Bovines/Cattle | Bovines/Cattle TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T51076-Ag | Equine/Horse | Equine/Horse TrkC/NTRK3 VLP (virus-like particle) | HEK293 | Products Developing |
