Explore CD86/FUN1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
| Target ID |
GM-T50912
|
| Target Name |
CD86/FUN1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
942
|
| Gene ID |
100060767 (Equus caballus), 12524 (Mus musculus), 403764 (Canis lupus familiaris), 414345 (Bos taurus)
493704 (Felis catus), 56822 (Rattus norvegicus), 714390 (Macaca mulatta), 942 (Homo sapiens)
|
| Target Alternative Names |
Activation B7-2 antigen,B7,B7-2,B7.2,B70,BU63,CD28LG2,CD86,CLS1,CTLA-4 counter-receptor B7.2,Cd28l2,Cd86,ETC-1,FUN-1,FUN1,LAB72,Ly-58,Ly58,MB7,MB7-2,T-lymphocyte activation antigen CD86,TS/A-2
|
| Uniprot Accession |
P42082,P42081
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cell adhesion molecules, Toll-like receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Kaposi sarcoma-associated herpesvirus infection, Autoimmune thyroid disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSECAG00000012128, ENSMUSG00000022901, ENSCAFG00845022561, ENSBTAG00000013118, ENSMMUG00000000912, ENSG00000114013
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD86/FUN1 cDNA Clones/ORF Plasmid
CD86/FUN1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo942 | Pre-made Human CD86/B70/B7-2 siRNA oligo Duplex | 942 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56822 | Pre-made Rat Cd86/B7-2 siRNA oligo Duplex | 56822 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12524 | Pre-made Mouse Cd86/B7/B70 siRNA oligo Duplex | 12524 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714390 | Pre-made Cynomolgus/Rhesus macaque CD86 siRNA oligo Duplex | 714390 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493704 | Pre-made Cat/Feline CD86/B7-2 siRNA oligo Duplex | 493704 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403764 | Pre-made Dog/Canine CD86 siRNA oligo Duplex | 403764 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo414345 | Pre-made Bovines/Cattle CD86 siRNA oligo Duplex | 414345 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060767 | Pre-made Equine/Horse CD86 siRNA oligo Duplex | 100060767 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD86/FUN1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T50912-Ab | Human | Anti-Human CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T50912-Ab | Rat | Anti-Rat CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T50912-Ab | Mouse | Anti-Mouse CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T50912-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T50912-Ab | Cat/Feline | Anti-Cat/Feline CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T50912-Ab | Dog/Canine | Anti-Dog/Canine CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T50912-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T50912-Ab | Equine/Horse | Anti-Equine/Horse CD86/FUN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD86/FUN1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T50912-Ag | Human | Human CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T50912-Ag | Rat | Rat CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T50912-Ag | Mouse | Mouse CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T50912-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T50912-Ag | Cat/Feline | Cat/Feline CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T50912-Ag | Dog/Canine | Dog/Canine CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T50912-Ag | Bovines/Cattle | Bovines/Cattle CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T50912-Ag | Equine/Horse | Equine/Horse CD86/FUN1 VLP (virus-like particle) | HEK293 | Products Developing |
