Explore LRP6/LRP-6 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Target ID |
GM-T49755
|
Target Name |
LRP6/LRP-6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4040
|
Gene ID |
100063409 (Equus caballus), 101082246 (Felis catus), 16974 (Mus musculus), 312781 (Rattus norvegicus) 4040 (Homo sapiens), 477692 (Canis lupus familiaris), 536328 (Bos taurus), 695843 (Macaca mulatta)
|
Target Alternative Names |
LRP6,Lrp6,Cd,Gw,ska26,skax26,ska<m26Jus>,C030016K15Rik,ADCAD2,STHAG7
|
Uniprot Accession |
O88572,O75581
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target
|
Disease |
cancer
|
Disease from KEGG |
Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action, Alzheimer disease, Pathways in cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer
|
Gene Ensembl |
ENSECAG00000007129, ENSMUSG00000030201, ENSG00000070018, ENSCAFG00845024356, ENSBTAG00000011761, ENSMMUG00000023317
|
Target Classification |
|
Pre-made viral vector of LRP6/LRP-6 cDNA Clones/ORF Plasmid
LRP6/LRP-6 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo4040 | Pre-made Human LRP6/ADCAD2/STHAG7 siRNA oligo Duplex | 4040 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo312781 | Pre-made Rat Lrp6 siRNA oligo Duplex | 312781 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo16974 | Pre-made Mouse Lrp6/Cd/Gw siRNA oligo Duplex | 16974 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo695843 | Pre-made Cynomolgus/Rhesus macaque LRP6 siRNA oligo Duplex | 695843 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101082246 | Pre-made Cat/Feline LRP6 siRNA oligo Duplex | 101082246 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo477692 | Pre-made Dog/Canine LRP6 siRNA oligo Duplex | 477692 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo536328 | Pre-made Bovines/Cattle LRP6 siRNA oligo Duplex | 536328 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100063409 | Pre-made Equine/Horse LRP6 siRNA oligo Duplex | 100063409 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LRP6/LRP-6 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T49755-Ab | Human | Anti-Human LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T49755-Ab | Rat | Anti-Rat LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T49755-Ab | Mouse | Anti-Mouse LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T49755-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T49755-Ab | Cat/Feline | Anti-Cat/Feline LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T49755-Ab | Dog/Canine | Anti-Dog/Canine LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T49755-Ab | Bovines/Cattle | Anti-Bovines/Cattle LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T49755-Ab | Equine/Horse | Anti-Equine/Horse LRP6/LRP-6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LRP6/LRP-6 VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T49755-Ag | Human | Human LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T49755-Ag | Rat | Rat LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T49755-Ag | Mouse | Mouse LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T49755-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T49755-Ag | Cat/Feline | Cat/Feline LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T49755-Ag | Dog/Canine | Dog/Canine LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T49755-Ag | Bovines/Cattle | Bovines/Cattle LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T49755-Ag | Equine/Horse | Equine/Horse LRP6/LRP-6 VLP (virus-like particle) | HEK293 | Products Developing |