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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T49507
|
| Target Name |
EPHB4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2050
|
| Gene ID |
100069098 (Equus caballus), 101094226 (Felis catus), 13846 (Mus musculus), 2050 (Homo sapiens)
489830 (Canis lupus familiaris), 515756 (Bos taurus), 686310 (Rattus norvegicus), 719320 (Macaca mulatta)
|
| Target Alternative Names |
CMAVM2,EPHB4,Ephb4,Ephrin type-B receptor 4,HFASD,HTK,Hepatoma transmembrane kinase,Htk,LMPHM7,MDK2,MYK1,Myk1,TYRO11,Tyro11,Tyrosine-protein kinase TYRO11,b2b2412Clo
|
| Uniprot Accession |
P54761,P54760
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Axon guidance
|
| Gene Ensembl |
ENSECAG00000010632, ENSMUSG00000029710, ENSG00000196411, ENSCAFG00845000816, ENSBTAG00000003446, ENSMMUG00000007375
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of EPHB4 cDNA Clones/ORF Plasmid
EPHB4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2050 | Pre-made Human EPHB4/HTK/MYK1 siRNA oligo Duplex | 2050 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo686310 | Pre-made Rat Ephb4 siRNA oligo Duplex | 686310 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13846 | Pre-made Mouse Ephb4/Htk/MDK2 siRNA oligo Duplex | 13846 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719320 | Pre-made Cynomolgus/Rhesus macaque EPHB4 siRNA oligo Duplex | 719320 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094226 | Pre-made Cat/Feline EPHB4 siRNA oligo Duplex | 101094226 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489830 | Pre-made Dog/Canine EPHB4 siRNA oligo Duplex | 489830 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515756 | Pre-made Bovines/Cattle EPHB4 siRNA oligo Duplex | 515756 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069098 | Pre-made Equine/Horse EPHB4 siRNA oligo Duplex | 100069098 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EPHB4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T49507-Ab | Human | Anti-Human EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T49507-Ab | Rat | Anti-Rat EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T49507-Ab | Mouse | Anti-Mouse EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T49507-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T49507-Ab | Cat/Feline | Anti-Cat/Feline EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T49507-Ab | Dog/Canine | Anti-Dog/Canine EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T49507-Ab | Bovines/Cattle | Anti-Bovines/Cattle EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T49507-Ab | Equine/Horse | Anti-Equine/Horse EPHB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
EPHB4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T49507-Ag | Human | Human EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T49507-Ag | Rat | Rat EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T49507-Ag | Mouse | Mouse EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T49507-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T49507-Ag | Cat/Feline | Cat/Feline EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T49507-Ag | Dog/Canine | Dog/Canine EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T49507-Ag | Bovines/Cattle | Bovines/Cattle EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T49507-Ag | Equine/Horse | Equine/Horse EPHB4 VLP (virus-like particle) | HEK293 | Products Developing |
