Explore TLR8/CD288 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T48703
|
| Target Name |
TLR8/CD288
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
51311
|
| Gene ID |
100054367 (Equus caballus), 100684828 (Canis lupus familiaris), 101091762 (Felis catus), 170744 (Mus musculus)
51311 (Homo sapiens), 532262 (Bos taurus), 574292 (Macaca mulatta), 684440 (Rattus norvegicus)
|
| Target Alternative Names |
TLR8,Tlr8,CD288,IMD98,TLR-8,hTLR8
|
| Uniprot Accession |
P58682,Q9NR97
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
|
| Disease from KEGG |
Toll-like receptor signaling pathway
|
| Gene Ensembl |
ENSECAG00000009180, ENSCAFG00845028394, ENSMUSG00000040522, ENSG00000101916, ENSBTAG00000031020
|
| Target Classification |
Checkpoint-Immuno Oncology
|
TLR8/CD288 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo51311 | Pre-made Human TLR8/CD288/IMD98 siRNA oligo Duplex | 51311 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo684440 | Pre-made Rat Tlr8 siRNA oligo Duplex | 684440 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170744 | Pre-made Mouse Tlr8 siRNA oligo Duplex | 170744 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574292 | Pre-made Cynomolgus/Rhesus macaque TLR8 siRNA oligo Duplex | 574292 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091762 | Pre-made Cat/Feline TLR8 siRNA oligo Duplex | 101091762 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100684828 | Pre-made Dog/Canine TLR8 siRNA oligo Duplex | 100684828 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo532262 | Pre-made Bovines/Cattle TLR8 siRNA oligo Duplex | 532262 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054367 | Pre-made Equine/Horse TLR8 siRNA oligo Duplex | 100054367 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TLR8/CD288 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T48703-Ab | Human | Anti-Human TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T48703-Ab | Rat | Anti-Rat TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T48703-Ab | Mouse | Anti-Mouse TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T48703-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T48703-Ab | Cat/Feline | Anti-Cat/Feline TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T48703-Ab | Dog/Canine | Anti-Dog/Canine TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T48703-Ab | Bovines/Cattle | Anti-Bovines/Cattle TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T48703-Ab | Equine/Horse | Anti-Equine/Horse TLR8/CD288 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TLR8/CD288 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T48703-Ag | Human | Human TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T48703-Ag | Rat | Rat TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T48703-Ag | Mouse | Mouse TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T48703-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T48703-Ag | Cat/Feline | Cat/Feline TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T48703-Ag | Dog/Canine | Dog/Canine TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T48703-Ag | Bovines/Cattle | Bovines/Cattle TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T48703-Ag | Equine/Horse | Equine/Horse TLR8/CD288 VLP (virus-like particle) | HEK293 | Products Developing |
