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Target
sublocation: Transmembrane Protein.
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
| Target ID |
GM-T48457
|
| Target Name |
CR1/CD35
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1378
|
| Gene ID |
1378 (Homo sapiens), 718120 (Macaca mulatta)
|
| Target Alternative Names |
C3BR,C3b/C4b receptor,C4BR,CD35,CR1,Complement receptor type 1,KN
|
| Uniprot Accession |
P17927
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Complement and coagulation cascades, Hematopoietic cell lineage, Legionellosis, Leishmaniasis, Malaria, Tuberculosis
|
| Gene Ensembl |
ENSG00000203710
|
CR1/CD35 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1378 | Pre-made Human CR1/KN/C3BR siRNA oligo Duplex | 1378 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718120 | Pre-made Cynomolgus/Rhesus macaque CR1 siRNA oligo Duplex | 718120 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CR1/CD35 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T48457-Ab | Human | Anti-Human CR1/CD35 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T48457-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CR1/CD35 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CR1/CD35 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T48457-Ag | Human | Human CR1/CD35 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T48457-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CR1/CD35 VLP (virus-like particle) | HEK293 | Products Developing |
