Explore IGF1R/CD221 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
| Target ID |
GM-T48069
|
| Target Name |
IGF1R/CD221
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3480
|
| Gene ID |
100055698 (Equus caballus), 100500937 (Felis catus), 16001 (Mus musculus), 25718 (Rattus norvegicus)
281848 (Bos taurus), 3480 (Homo sapiens), 442951 (Canis lupus familiaris), 708227 (Macaca mulatta)
|
| Target Alternative Names |
A330103N21Rik,CD221,D930020L01,IGF-1 receptor,IGF-1R,IGF1R,IGFIR,IGFIRC,IGFR,IGFR1,Igf1r,Igfr1,Insulin-like growth factor 1 receptor,Insulin-like growth factor I receptor (IGF-I receptor),JTK13,hyft
|
| Uniprot Accession |
Q60751,P24062,Q05688,P08069
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Ovarian steroidogenesis, Pathways in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma
|
| Gene Ensembl |
ENSECAG00000021238, ENSMUSG00000005533, ENSBTAG00000021527, ENSG00000140443, ENSCAFG00845001742, ENSMMUG00000012305
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
IGF1R/CD221 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3480 | Pre-made Human IGF1R/IGFR/CD221 siRNA oligo Duplex | 3480 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25718 | Pre-made Rat Igf1r/Igfr1/JTK13 siRNA oligo Duplex | 25718 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16001 | Pre-made Mouse Igf1r/hyft/CD221 siRNA oligo Duplex | 16001 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708227 | Pre-made Cynomolgus/Rhesus macaque IGF1R siRNA oligo Duplex | 708227 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100500937 | Pre-made Cat/Feline IGF1R siRNA oligo Duplex | 100500937 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442951 | Pre-made Dog/Canine IGF1R siRNA oligo Duplex | 442951 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281848 | Pre-made Bovines/Cattle IGF1R/IGFR1 siRNA oligo Duplex | 281848 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055698 | Pre-made Equine/Horse IGF1R siRNA oligo Duplex | 100055698 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IGF1R/CD221 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T48069-Ab | Human | Anti-Human IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T48069-Ab | Rat | Anti-Rat IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T48069-Ab | Mouse | Anti-Mouse IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T48069-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T48069-Ab | Cat/Feline | Anti-Cat/Feline IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T48069-Ab | Dog/Canine | Anti-Dog/Canine IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T48069-Ab | Bovines/Cattle | Anti-Bovines/Cattle IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T48069-Ab | Equine/Horse | Anti-Equine/Horse IGF1R/CD221 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IGF1R/CD221 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T48069-Ag | Human | Human IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T48069-Ag | Rat | Rat IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T48069-Ag | Mouse | Mouse IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T48069-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T48069-Ag | Cat/Feline | Cat/Feline IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T48069-Ag | Dog/Canine | Dog/Canine IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T48069-Ag | Bovines/Cattle | Bovines/Cattle IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T48069-Ag | Equine/Horse | Equine/Horse IGF1R/CD221 VLP (virus-like particle) | HEK293 | Products Developing |
