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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
| Target ID |
GM-T47768
|
| Target Name |
OPRM1/MOP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4988
|
| Gene ID |
100060029 (Equus caballus), 101084452 (Felis catus), 18390 (Mus musculus), 25601 (Rattus norvegicus) 281958 (Bos taurus), 484041 (Canis lupus familiaris), 4988 (Homo sapiens), 574141 (Macaca mulatta)
|
| Target Alternative Names |
LMOR,M-OR-1,MOP,MOP-R,MOR,MOR-1,MOR-1O,MOR1,MORA,Mu opiate receptor,Mu opioid receptor (MOP,Mu-type opioid receptor,OPRM,OPRM1,Oprm,Oprm1,Oprrm1,hMOP),mor,muOR
|
| Uniprot Accession |
P42866,P33535,P79350,P35372,Q9MYW9
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Morphine addiction
|
| Gene Ensembl |
ENSECAG00000013458, ENSMUSG00000000766, ENSBTAG00000019719, ENSCAFG00845000160, ENSG00000112038, ENSMMUG00000022691
|
| Target Classification |
GPCR
|
Pre-made viral vector of OPRM1/MOP cDNA Clones/ORF Plasmid
OPRM1/MOP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4988 | Pre-made Human OPRM1/MOP/MOR siRNA oligo Duplex | 4988 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25601 | Pre-made Rat Oprm1/MORA/Oprm siRNA oligo Duplex | 25601 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18390 | Pre-made Mouse Oprm1/mor/Oprm siRNA oligo Duplex | 18390 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574141 | Pre-made Cynomolgus/Rhesus macaque OPRM1 siRNA oligo Duplex | 574141 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084452 | Pre-made Cat/Feline OPRM1 siRNA oligo Duplex | 101084452 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484041 | Pre-made Dog/Canine OPRM1 siRNA oligo Duplex | 484041 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281958 | Pre-made Bovines/Cattle OPRM1 siRNA oligo Duplex | 281958 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060029 | Pre-made Equine/Horse OPRM1 siRNA oligo Duplex | 100060029 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
OPRM1/MOP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47768-Ab | Human | Anti-Human OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T47768-Ab | Rat | Anti-Rat OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T47768-Ab | Mouse | Anti-Mouse OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T47768-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T47768-Ab | Cat/Feline | Anti-Cat/Feline OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T47768-Ab | Dog/Canine | Anti-Dog/Canine OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T47768-Ab | Bovines/Cattle | Anti-Bovines/Cattle OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T47768-Ab | Equine/Horse | Anti-Equine/Horse OPRM1/MOP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
OPRM1/MOP VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47768-Ag | Human | Human OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T47768-Ag | Rat | Rat OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T47768-Ag | Mouse | Mouse OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T47768-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T47768-Ag | Cat/Feline | Cat/Feline OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T47768-Ag | Dog/Canine | Dog/Canine OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T47768-Ag | Bovines/Cattle | Bovines/Cattle OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T47768-Ag | Equine/Horse | Equine/Horse OPRM1/MOP VLP (virus-like particle) | HEK293 | Products Developing |