Explore ACVR1B gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
| Target ID |
GM-T47594
|
| Target Name |
ACVR1B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
91
|
| Gene ID |
100062619 (Equus caballus), 101097654 (Felis catus), 11479 (Mus musculus), 29381 (Rattus norvegicus)
486537 (Canis lupus familiaris), 539315 (Bos taurus), 696587 (Macaca mulatta), 91 (Homo sapiens)
|
| Target Alternative Names |
6820432J04,ACTRIB,ACVR1B,ACVRLK4,ALK-4,ALK4,ActR-IB,ActRIB,Activin receptor type IB (ACTR-IB),Activin receptor type-1B,Activin receptor-like kinase 4 (ALK-4),Acvr1b,Acvrlk4,Alk4,SKR2,Serine/threonine-protein kinase receptor R2 (SKR2),Skr2
|
| Uniprot Accession |
Q61271,P80202,P36896
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
| Gene Ensembl |
ENSECAG00000011686, ENSMUSG00000000532, ENSCAFG00845027407, ENSBTAG00000013555, ENSMMUG00000046877, ENSG00000135503
|
| Target Classification |
Cytokine Receptor, Kinase
|
Pre-made viral vector of ACVR1B cDNA Clones/ORF Plasmid
ACVR1B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo91 | Pre-made Human ACVR1B/ALK4/SKR2 siRNA oligo Duplex | 91 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29381 | Pre-made Rat Acvr1b/Skr2 siRNA oligo Duplex | 29381 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11479 | Pre-made Mouse Acvr1b/Alk4/SKR2 siRNA oligo Duplex | 11479 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696587 | Pre-made Cynomolgus/Rhesus macaque ACVR1B siRNA oligo Duplex | 696587 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097654 | Pre-made Cat/Feline ACVR1B siRNA oligo Duplex | 101097654 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486537 | Pre-made Dog/Canine ACVR1B siRNA oligo Duplex | 486537 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539315 | Pre-made Bovines/Cattle ACVR1B siRNA oligo Duplex | 539315 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062619 | Pre-made Equine/Horse ACVR1B siRNA oligo Duplex | 100062619 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ACVR1B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47594-Ab | Human | Anti-Human ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T47594-Ab | Rat | Anti-Rat ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T47594-Ab | Mouse | Anti-Mouse ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T47594-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T47594-Ab | Cat/Feline | Anti-Cat/Feline ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T47594-Ab | Dog/Canine | Anti-Dog/Canine ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T47594-Ab | Bovines/Cattle | Anti-Bovines/Cattle ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T47594-Ab | Equine/Horse | Anti-Equine/Horse ACVR1B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
ACVR1B VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47594-Ag | Human | Human ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T47594-Ag | Rat | Rat ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T47594-Ag | Mouse | Mouse ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T47594-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T47594-Ag | Cat/Feline | Cat/Feline ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T47594-Ag | Dog/Canine | Dog/Canine ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T47594-Ag | Bovines/Cattle | Bovines/Cattle ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T47594-Ag | Equine/Horse | Equine/Horse ACVR1B VLP (virus-like particle) | HEK293 | Products Developing |
