Explore HMBS gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T47466
|
| Target Name |
HMBS
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3145
|
| Gene ID |
100071339 (Equus caballus), 100127114 (Felis catus), 15288 (Mus musculus), 25709 (Rattus norvegicus)
3145 (Homo sapiens), 489373 (Canis lupus familiaris), 515614 (Bos taurus), 702943 (Macaca mulatta)
|
| Target Alternative Names |
ENCEP,HMBS,Hmbs,Hydroxymethylbilane synthase (HMBS),LENCEP,PBG-D,PBGD,PORC,Porphobilinogen deaminase,Pre-uroporphyrinogen synthase,UPS,URO-S,Ups,Uros1,hemC
|
| Uniprot Accession |
P22907,P19356,P08397,Q2KIN5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Porphyrin metabolism
|
| Gene Ensembl |
ENSECAG00000017593, ENSMUSG00000032126, ENSG00000256269, ENSCAFG00845000569, ENSBTAG00000005364, ENSMMUG00000014866
|
Pre-made viral vector of HMBS cDNA Clones/ORF Plasmid
HMBS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3145 | Pre-made Human HMBS/UPS/PBGD siRNA oligo Duplex | 3145 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25709 | Pre-made Rat Hmbs/PBGD/hemC siRNA oligo Duplex | 25709 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15288 | Pre-made Mouse Hmbs/Ups/PBGD siRNA oligo Duplex | 15288 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702943 | Pre-made Cynomolgus/Rhesus macaque HMBS siRNA oligo Duplex | 702943 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100127114 | Pre-made Cat/Feline HMBS siRNA oligo Duplex | 100127114 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489373 | Pre-made Dog/Canine HMBS siRNA oligo Duplex | 489373 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515614 | Pre-made Bovines/Cattle HMBS siRNA oligo Duplex | 515614 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071339 | Pre-made Equine/Horse HMBS siRNA oligo Duplex | 100071339 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HMBS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47466-Ab | Human | Anti-Human HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T47466-Ab | Rat | Anti-Rat HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T47466-Ab | Mouse | Anti-Mouse HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T47466-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T47466-Ab | Cat/Feline | Anti-Cat/Feline HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T47466-Ab | Dog/Canine | Anti-Dog/Canine HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T47466-Ab | Bovines/Cattle | Anti-Bovines/Cattle HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T47466-Ab | Equine/Horse | Anti-Equine/Horse HMBS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HMBS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47466-Ag | Human | Human HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T47466-Ag | Rat | Rat HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T47466-Ag | Mouse | Mouse HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T47466-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T47466-Ag | Cat/Feline | Cat/Feline HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T47466-Ag | Dog/Canine | Dog/Canine HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T47466-Ag | Bovines/Cattle | Bovines/Cattle HMBS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T47466-Ag | Equine/Horse | Equine/Horse HMBS recombinant protein | Mammalian cell | Detail |
