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Target
sublocation: Transmembrane Protein.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T47415
|
| Target Name |
HLA-B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3106
|
| Gene ID |
3106 (Homo sapiens)
|
| Target Alternative Names |
AS,B alpha chain,B-4901,HLA class I histocompatibility antigen,HLA-B,HLAB,Human leukocyte antigen B (HLA-B)
|
| Uniprot Accession |
P01889
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cellular senescence, Cell adhesion molecules, Antigen processing and presentation, Type I diabetes mellitus, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000234745
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-B cDNA Clones/ORF Plasmid
HLA-B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3106 | Pre-made Human HLA-B/AS/HLAB siRNA oligo Duplex | 3106 | Human | In-vitro grade; in-vivo grade | Detail |
HLA-B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47415-Ab | Human | Anti-Human HLA-B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HLA-B VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47415-Ag | Human | Human HLA-B VLP (virus-like particle) | HEK293 | Products Developing |
