Explore CHRM2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T46185
|
| Target Name |
CHRM2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1129
|
| Gene ID |
100064906 (Equus caballus), 101099790 (Felis catus), 1129 (Homo sapiens), 243764 (Mus musculus)
403858 (Canis lupus familiaris), 522170 (Bos taurus), 714780 (Macaca mulatta), 81645 (Rattus norvegicus)
|
| Target Alternative Names |
CHRM2,Chrm2,HM2,M2,Chrm-2,AChR-M2,Acm2
|
| Uniprot Accession |
P08172,Q9ERZ4,P41985,P10980
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton
|
| Gene Ensembl |
ENSECAG00000038631, ENSG00000181072, ENSMUSG00000045613, ENSCAFG00845008775, ENSBTAG00000014674, ENSMMUG00000054019
|
| Target Classification |
GPCR
|
Pre-made viral vector of CHRM2 cDNA Clones/ORF Plasmid
CHRM2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1129 | Pre-made Human CHRM2/HM2 siRNA oligo Duplex | 1129 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81645 | Pre-made Rat Chrm2/Acm2 siRNA oligo Duplex | 81645 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo243764 | Pre-made Mouse Chrm2/M2/Chrm-2 siRNA oligo Duplex | 243764 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714780 | Pre-made Cynomolgus/Rhesus macaque CHRM2 siRNA oligo Duplex | 714780 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099790 | Pre-made Cat/Feline CHRM2 siRNA oligo Duplex | 101099790 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403858 | Pre-made Dog/Canine CHRM2 siRNA oligo Duplex | 403858 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo522170 | Pre-made Bovines/Cattle CHRM2 siRNA oligo Duplex | 522170 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064906 | Pre-made Equine/Horse CHRM2 siRNA oligo Duplex | 100064906 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHRM2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T46185-Ab | Human | Anti-Human CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T46185-Ab | Rat | Anti-Rat CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T46185-Ab | Mouse | Anti-Mouse CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T46185-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T46185-Ab | Cat/Feline | Anti-Cat/Feline CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T46185-Ab | Dog/Canine | Anti-Dog/Canine CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T46185-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T46185-Ab | Equine/Horse | Anti-Equine/Horse CHRM2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CHRM2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T46185-Ag | Human | Human CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T46185-Ag | Rat | Rat CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T46185-Ag | Mouse | Mouse CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T46185-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T46185-Ag | Cat/Feline | Cat/Feline CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T46185-Ag | Dog/Canine | Dog/Canine CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T46185-Ag | Bovines/Cattle | Bovines/Cattle CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T46185-Ag | Equine/Horse | Equine/Horse CHRM2 VLP (virus-like particle) | HEK293 | Products Developing |
