Explore SILV/PMEL gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
| Target ID |
GM-T46128
|
| Target Name |
SILV/PMEL
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6490
|
| Gene ID |
100033885 (Equus caballus), 101092774 (Felis catus), 20431 (Mus musculus), 281487 (Bos taurus)
362818 (Rattus norvegicus), 481102 (Canis lupus familiaris), 6490 (Homo sapiens), 710921 (Macaca mulatta)
|
| Target Alternative Names |
PMEL,Pmel,SILV,PMEL17,Si,Silv,gp87,gp100,Pmel17,D12S53Eh,D10H12S53E,RPE1,P1,SI,SIL,ME20,P100,HMB45,ME20M,HMB-45,ME20-M,D12S53E
|
| Uniprot Accession |
Q60696,Q06154,P40967
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000020000, ENSMUSG00000025359, ENSBTAG00000004019, ENSCAFG00845005780, ENSG00000185664, ENSMMUG00000018816
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
SILV/PMEL siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6490 | Pre-made Human PMEL/P1/SI siRNA oligo Duplex | 6490 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo362818 | Pre-made Rat Pmel/Silv siRNA oligo Duplex | 362818 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20431 | Pre-made Mouse Pmel/Si/Silv siRNA oligo Duplex | 20431 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710921 | Pre-made Cynomolgus/Rhesus macaque PMEL/SILV siRNA oligo Duplex | 710921 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092774 | Pre-made Cat/Feline PMEL siRNA oligo Duplex | 101092774 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481102 | Pre-made Dog/Canine PMEL/SILV/Pmel17 siRNA oligo Duplex | 481102 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281487 | Pre-made Bovines/Cattle PMEL/RPE1/SILV siRNA oligo Duplex | 281487 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033885 | Pre-made Equine/Horse PMEL/SILV/PMEL17 siRNA oligo Duplex | 100033885 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SILV/PMEL antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T46128-Ab | Human | Anti-Human SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T46128-Ab | Rat | Anti-Rat SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T46128-Ab | Mouse | Anti-Mouse SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T46128-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T46128-Ab | Cat/Feline | Anti-Cat/Feline SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T46128-Ab | Dog/Canine | Anti-Dog/Canine SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T46128-Ab | Bovines/Cattle | Anti-Bovines/Cattle SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T46128-Ab | Equine/Horse | Anti-Equine/Horse SILV/PMEL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SILV/PMEL VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T46128-Ag | Human | Human SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T46128-Ag | Rat | Rat SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T46128-Ag | Mouse | Mouse SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T46128-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T46128-Ag | Cat/Feline | Cat/Feline SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T46128-Ag | Dog/Canine | Dog/Canine SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T46128-Ag | Bovines/Cattle | Bovines/Cattle SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T46128-Ag | Equine/Horse | Equine/Horse SILV/PMEL VLP (virus-like particle) | HEK293 | Products Developing |
