Explore F11 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T46040
|
| Target Name |
F11
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2160
|
| Gene ID |
100056603 (Equus caballus), 101094340 (Felis catus), 109821 (Mus musculus), 2160 (Homo sapiens)
290757 (Rattus norvegicus), 407998 (Bos taurus), 702117 (Macaca mulatta)
|
| Target Alternative Names |
1600027G01Rik,Cf11,Coagulation factor XI,F11,FXI,LRRGT00086,PTA,Plasma thromboplastin antecedent (PTA)
|
| Uniprot Accession |
Q91Y47,P03951,Q5NTB3
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSECAG00000001073, ENSMUSG00000031645, ENSG00000088926, ENSBTAG00000003572, ENSMMUG00000011634
|
F11 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2160 | Pre-made Human F11/FXI/PTA siRNA oligo Duplex | 2160 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo290757 | Pre-made Rat F11/LRRGT00086 siRNA oligo Duplex | 290757 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo109821 | Pre-made Mouse F11/FXI/PTA siRNA oligo Duplex | 109821 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702117 | Pre-made Cynomolgus/Rhesus macaque F11 siRNA oligo Duplex | 702117 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094340 | Pre-made Cat/Feline F11 siRNA oligo Duplex | 101094340 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407998 | Pre-made Bovines/Cattle F11/FXI siRNA oligo Duplex | 407998 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056603 | Pre-made Equine/Horse F11 siRNA oligo Duplex | 100056603 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
F11 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T46040-Ab | Human | Anti-Human F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T46040-Ab | Rat | Anti-Rat F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T46040-Ab | Mouse | Anti-Mouse F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T46040-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T46040-Ab | Cat/Feline | Anti-Cat/Feline F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T46040-Ab | Bovines/Cattle | Anti-Bovines/Cattle F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T46040-Ab | Equine/Horse | Anti-Equine/Horse F11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
F11 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T46040-Ag | Human | Human F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T46040-Ag | Rat | Rat F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T46040-Ag | Mouse | Mouse F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T46040-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T46040-Ag | Cat/Feline | Cat/Feline F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T46040-Ag | Bovines/Cattle | Bovines/Cattle F11 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T46040-Ag | Equine/Horse | Equine/Horse F11 VLP (virus-like particle) | HEK293 | Products Developing |
