Explore NOTCH3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
| Target ID |
GM-T44684
|
| Target Name |
NOTCH3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4854
|
| Gene ID |
100146771 (Equus caballus), 101088469 (Felis catus), 18131 (Mus musculus), 4854 (Homo sapiens)
56761 (Rattus norvegicus), 610439 (Canis lupus familiaris), 719119 (Macaca mulatta), 789485 (Bos taurus)
|
| Target Alternative Names |
CADASIL,CADASIL1,CASIL,IMF2,LMNS,N3,NOTCH3,Neurogenic locus notch homolog protein 3,Notch 3,Notch3,hpbk
|
| Uniprot Accession |
Q61982,Q9UM47,Q9R172
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, Th1 and Th2 cell differentiation, Thyroid hormone signaling pathway, Human papillomavirus infection, Pathways in cancer, Breast cancer
|
| Gene Ensembl |
ENSECAG00000021331, ENSMUSG00000038146, ENSG00000074181, ENSCAFG00845018638, ENSMMUG00000013637, ENSBTAG00000043971
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NOTCH3 cDNA Clones/ORF Plasmid
NOTCH3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4854 | Pre-made Human NOTCH3/IMF2/LMNS siRNA oligo Duplex | 4854 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56761 | Pre-made Rat Notch3 siRNA oligo Duplex | 56761 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18131 | Pre-made Mouse Notch3/N3/hpbk siRNA oligo Duplex | 18131 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719119 | Pre-made Cynomolgus/Rhesus macaque NOTCH3 siRNA oligo Duplex | 719119 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088469 | Pre-made Cat/Feline NOTCH3 siRNA oligo Duplex | 101088469 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo610439 | Pre-made Dog/Canine NOTCH3 siRNA oligo Duplex | 610439 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo789485 | Pre-made Bovines/Cattle NOTCH3 siRNA oligo Duplex | 789485 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146771 | Pre-made Equine/Horse NOTCH3 siRNA oligo Duplex | 100146771 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NOTCH3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T44684-Ab | Human | Anti-Human NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T44684-Ab | Rat | Anti-Rat NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T44684-Ab | Mouse | Anti-Mouse NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T44684-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T44684-Ab | Cat/Feline | Anti-Cat/Feline NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T44684-Ab | Dog/Canine | Anti-Dog/Canine NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T44684-Ab | Bovines/Cattle | Anti-Bovines/Cattle NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T44684-Ab | Equine/Horse | Anti-Equine/Horse NOTCH3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
NOTCH3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T44684-Ag | Human | Human NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T44684-Ag | Rat | Rat NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T44684-Ag | Mouse | Mouse NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T44684-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T44684-Ag | Cat/Feline | Cat/Feline NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T44684-Ag | Dog/Canine | Dog/Canine NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T44684-Ag | Bovines/Cattle | Bovines/Cattle NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T44684-Ag | Equine/Horse | Equine/Horse NOTCH3 VLP (virus-like particle) | HEK293 | Products Developing |
