Explore SH2B3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
| Target ID |
GM-T44585
|
| Target Name |
SH2B3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10019
|
| Gene ID |
100057885 (Equus caballus), 10019 (Homo sapiens), 100683018 (Canis lupus familiaris), 101081760 (Felis catus)
16923 (Mus musculus), 58838 (Rattus norvegicus), 614726 (Bos taurus), 710839 (Macaca mulatta)
|
| Target Alternative Names |
IDDM20,LNK,Lnk,Lymphocyte adapter protein,Lymphocyte-specific adapter protein Lnk,SH2B adapter protein 3,SH2B3,Sh2b3,Signal transduction protein Lnk
|
| Uniprot Accession |
Q9UQQ2,O09039,P50745
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Neurotrophin signaling pathway
|
| Gene Ensembl |
ENSECAG00000007021, ENSG00000111252, ENSCAFG00845029052, ENSMUSG00000042594, ENSBTAG00000009101, ENSMMUG00000002223
|
Pre-made viral vector of SH2B3 cDNA Clones/ORF Plasmid
SH2B3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10019 | Pre-made Human SH2B3/LNK/IDDM20 siRNA oligo Duplex | 10019 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo58838 | Pre-made Rat Sh2b3/Lnk siRNA oligo Duplex | 58838 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16923 | Pre-made Mouse Sh2b3/Lnk siRNA oligo Duplex | 16923 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710839 | Pre-made Cynomolgus/Rhesus macaque SH2B3/LNK siRNA oligo Duplex | 710839 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081760 | Pre-made Cat/Feline SH2B3 siRNA oligo Duplex | 101081760 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100683018 | Pre-made Dog/Canine SH2B3 siRNA oligo Duplex | 100683018 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo614726 | Pre-made Bovines/Cattle SH2B3 siRNA oligo Duplex | 614726 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057885 | Pre-made Equine/Horse SH2B3 siRNA oligo Duplex | 100057885 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SH2B3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T44585-Ab | Human | Anti-Human SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T44585-Ab | Rat | Anti-Rat SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T44585-Ab | Mouse | Anti-Mouse SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T44585-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T44585-Ab | Cat/Feline | Anti-Cat/Feline SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T44585-Ab | Dog/Canine | Anti-Dog/Canine SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T44585-Ab | Bovines/Cattle | Anti-Bovines/Cattle SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T44585-Ab | Equine/Horse | Anti-Equine/Horse SH2B3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SH2B3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T44585-Ag | Human | Human SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T44585-Ag | Rat | Rat SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T44585-Ag | Mouse | Mouse SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T44585-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T44585-Ag | Cat/Feline | Cat/Feline SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T44585-Ag | Dog/Canine | Dog/Canine SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T44585-Ag | Bovines/Cattle | Bovines/Cattle SH2B3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T44585-Ag | Equine/Horse | Equine/Horse SH2B3 recombinant protein | Mammalian cell | Detail |
