Explore Osteoprotegerin/TNFRSF11B gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T43928
|
| Target Name |
Osteoprotegerin/TNFRSF11B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4982
|
| Gene ID |
100065885 (Equus caballus), 100855848 (Canis lupus familiaris), 101096878 (Felis catus), 18383 (Mus musculus)
25341 (Rattus norvegicus), 4982 (Homo sapiens), 523822 (Bos taurus), 701850 (Macaca mulatta)
|
| Target Alternative Names |
OCIF,OPG,Opg,Osteoclastogenesis inhibitory factor,Osteoprotegerin,PDB5,TNFRSF11B,TR1,Tnfrsf11b,Tumor necrosis factor receptor superfamily member 11B
|
| Uniprot Accession |
O08712,O08727,O00300,A5D7R1
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, Breast Cancer, Diabetic Nephropathy, Type 2 diabetes mellitus, Lupus Glomerulonephritis
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Osteoclast differentiation
|
| Gene Ensembl |
ENSECAG00000014916, ENSCAFG00845005623, ENSMUSG00000063727, ENSG00000164761, ENSBTAG00000007423, ENSMMUG00000016485
|
Pre-made viral vector of Osteoprotegerin/TNFRSF11B cDNA Clones/ORF Plasmid
Osteoprotegerin/TNFRSF11B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4982 | Pre-made Human TNFRSF11B/OPG/TR1 siRNA oligo Duplex | 4982 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25341 | Pre-made Rat Tnfrsf11b/Opg siRNA oligo Duplex | 25341 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18383 | Pre-made Mouse Tnfrsf11b/Opg/TR1 siRNA oligo Duplex | 18383 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701850 | Pre-made Cynomolgus/Rhesus macaque TNFRSF11B siRNA oligo Duplex | 701850 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096878 | Pre-made Cat/Feline TNFRSF11B siRNA oligo Duplex | 101096878 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855848 | Pre-made Dog/Canine TNFRSF11B siRNA oligo Duplex | 100855848 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo523822 | Pre-made Bovines/Cattle TNFRSF11B siRNA oligo Duplex | 523822 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065885 | Pre-made Equine/Horse TNFRSF11B siRNA oligo Duplex | 100065885 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Osteoprotegerin/TNFRSF11B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43928-Ab | Human | Anti-Human Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T43928-Ab | Rat | Anti-Rat Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T43928-Ab | Mouse | Anti-Mouse Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T43928-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T43928-Ab | Cat/Feline | Anti-Cat/Feline Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T43928-Ab | Dog/Canine | Anti-Dog/Canine Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T43928-Ab | Bovines/Cattle | Anti-Bovines/Cattle Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T43928-Ab | Equine/Horse | Anti-Equine/Horse Osteoprotegerin/TNFRSF11B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
Osteoprotegerin/TNFRSF11B VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43928-Ag | Human | Human Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T43928-Ag | Rat | Rat Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T43928-Ag | Mouse | Mouse Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T43928-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T43928-Ag | Cat/Feline | Cat/Feline Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T43928-Ag | Dog/Canine | Dog/Canine Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T43928-Ag | Bovines/Cattle | Bovines/Cattle Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T43928-Ag | Equine/Horse | Equine/Horse Osteoprotegerin/TNFRSF11B VLP (virus-like particle) | HEK293 | Products Developing |
