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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
| Target ID |
GM-T43718
|
| Target Name |
TLR5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7100
|
| Gene ID |
101082202 (Felis catus), 111771347 (Equus caballus), 289337 (Rattus norvegicus), 444870 (Bos taurus) 488605 (Canis lupus familiaris), 53791 (Mus musculus), 574328 (Macaca mulatta), 7100 (Homo sapiens)
|
| Target Alternative Names |
MELIOS,SLE1,SLEB1,TIL3,TLR-5,TLR5,Tlr5,Toll-like receptor 5,Toll/interleukin-1 receptor-like protein 3
|
| Uniprot Accession |
Q9JLF7,O60602
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Legionellosis, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000036553, ENSBTAG00000000477, ENSCAFG00845019169, ENSMUSG00000079164, ENSMMUG00000000870, ENSG00000187554
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of TLR5 cDNA Clones/ORF Plasmid
TLR5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7100 | Pre-made Human TLR5/SLE1/TIL3 siRNA oligo Duplex | 7100 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo289337 | Pre-made Rat Tlr5 siRNA oligo Duplex | 289337 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo53791 | Pre-made Mouse Tlr5 siRNA oligo Duplex | 53791 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574328 | Pre-made Cynomolgus/Rhesus macaque TLR5 siRNA oligo Duplex | 574328 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082202 | Pre-made Cat/Feline TLR5 siRNA oligo Duplex | 101082202 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488605 | Pre-made Dog/Canine TLR5 siRNA oligo Duplex | 488605 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo444870 | Pre-made Bovines/Cattle TLR5/TLR-5 siRNA oligo Duplex | 444870 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111771347 | Pre-made Equine/Horse TLR5 siRNA oligo Duplex | 111771347 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TLR5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43718-Ab | Human | Anti-Human TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T43718-Ab | Rat | Anti-Rat TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T43718-Ab | Mouse | Anti-Mouse TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T43718-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T43718-Ab | Cat/Feline | Anti-Cat/Feline TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T43718-Ab | Dog/Canine | Anti-Dog/Canine TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T43718-Ab | Bovines/Cattle | Anti-Bovines/Cattle TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T43718-Ab | Equine/Horse | Anti-Equine/Horse TLR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TLR5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43718-Ag | Human | Human TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T43718-Ag | Rat | Rat TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T43718-Ag | Mouse | Mouse TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T43718-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T43718-Ag | Cat/Feline | Cat/Feline TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T43718-Ag | Dog/Canine | Dog/Canine TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T43718-Ag | Bovines/Cattle | Bovines/Cattle TLR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T43718-Ag | Equine/Horse | Equine/Horse TLR5 VLP (virus-like particle) | HEK293 | Products Developing |