Explore IL12RB2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
| Target ID |
GM-T43524
|
| Target Name |
IL12RB2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3595
|
| Gene ID |
100053757 (Equus caballus), 101088012 (Felis catus), 16162 (Mus musculus), 171334 (Rattus norvegicus)
282452 (Bos taurus), 3595 (Homo sapiens), 489550 (Canis lupus familiaris), 700677 (Macaca mulatta)
|
| Target Alternative Names |
A930027I18Rik,IL-12 receptor subunit beta-2,IL-12R subunit beta-2,IL-12R-beta-2,IL-12RB2,IL12RB2,Ifnm,Il12rb2,Interleukin-12 receptor subunit beta-2
|
| Uniprot Accession |
P97378,Q9BEG2,Q99665
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Pathways in cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000016537, ENSMUSG00000018341, ENSBTAG00000009455, ENSG00000081985, ENSCAFG00845026911, ENSMMUG00000000651
|
| Target Classification |
Cytokine Receptor
|
IL12RB2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3595 | Pre-made Human IL12RB2 siRNA oligo Duplex | 3595 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171334 | Pre-made Rat Il12rb2 siRNA oligo Duplex | 171334 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16162 | Pre-made Mouse Il12rb2/Ifnm/IL-12RB2 siRNA oligo Duplex | 16162 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700677 | Pre-made Cynomolgus/Rhesus macaque IL12RB2 siRNA oligo Duplex | 700677 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088012 | Pre-made Cat/Feline IL12RB2 siRNA oligo Duplex | 101088012 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489550 | Pre-made Dog/Canine IL12RB2 siRNA oligo Duplex | 489550 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282452 | Pre-made Bovines/Cattle IL12RB2/IL-12RB2 siRNA oligo Duplex | 282452 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053757 | Pre-made Equine/Horse IL12RB2 siRNA oligo Duplex | 100053757 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL12RB2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43524-Ab | Human | Anti-Human IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T43524-Ab | Rat | Anti-Rat IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T43524-Ab | Mouse | Anti-Mouse IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T43524-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T43524-Ab | Cat/Feline | Anti-Cat/Feline IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T43524-Ab | Dog/Canine | Anti-Dog/Canine IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T43524-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T43524-Ab | Equine/Horse | Anti-Equine/Horse IL12RB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IL12RB2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43524-Ag | Human | Human IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T43524-Ag | Rat | Rat IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T43524-Ag | Mouse | Mouse IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T43524-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T43524-Ag | Cat/Feline | Cat/Feline IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T43524-Ag | Dog/Canine | Dog/Canine IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T43524-Ag | Bovines/Cattle | Bovines/Cattle IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T43524-Ag | Equine/Horse | Equine/Horse IL12RB2 VLP (virus-like particle) | HEK293 | Products Developing |
