Explore CD45/CD45RA/CD45RO/PTPRC gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
| Target ID |
GM-T43115
|
| Target Name |
CD45/CD45RA/CD45RO/PTPRC
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5788
|
| Gene ID |
100061950 (Equus caballus), 101097123 (Felis catus), 19264 (Mus musculus), 24699 (Rattus norvegicus)
407152 (Bos taurus), 5788 (Homo sapiens), 712657 (Macaca mulatta)
|
| Target Alternative Names |
B220,CD45,CD45R,CD45RA,CD45RO,Cd45,GP180,IMD105,L-CA,LCA,LY5,Lca,Leukocyte common antigen (L-CA),Ly-5,Lyt-4,PTPRC,Ptprc,RT7,Receptor-type tyrosine-protein phosphatase C,T200,cd45,loc
|
| Uniprot Accession |
P06800,P04157,P08575
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Cell adhesion molecules, T cell receptor signaling pathway
|
| Gene Ensembl |
ENSECAG00000007192, ENSMUSG00000026395, ENSBTAG00000023144, ENSG00000081237, ENSMMUG00000000009
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
CD45/CD45RA/CD45RO/PTPRC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5788 | Pre-made Human PTPRC/LCA/LY5 siRNA oligo Duplex | 5788 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24699 | Pre-made Rat Ptprc/Lca/RT7 siRNA oligo Duplex | 24699 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19264 | Pre-made Mouse Ptprc/loc/B220 siRNA oligo Duplex | 19264 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712657 | Pre-made Cynomolgus/Rhesus macaque PTPRC siRNA oligo Duplex | 712657 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097123 | Pre-made Cat/Feline PTPRC siRNA oligo Duplex | 101097123 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407152 | Pre-made Bovines/Cattle PTPRC/cd45 siRNA oligo Duplex | 407152 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061950 | Pre-made Equine/Horse PTPRC siRNA oligo Duplex | 100061950 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD45/CD45RA/CD45RO/PTPRC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43115-Ab | Human | Anti-Human CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T43115-Ab | Rat | Anti-Rat CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T43115-Ab | Mouse | Anti-Mouse CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T43115-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T43115-Ab | Cat/Feline | Anti-Cat/Feline CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T43115-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T43115-Ab | Equine/Horse | Anti-Equine/Horse CD45/CD45RA/CD45RO/PTPRC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43115-Ag | Human | Human CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T43115-Ag | Rat | Rat CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T43115-Ag | Mouse | Mouse CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T43115-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T43115-Ag | Cat/Feline | Cat/Feline CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T43115-Ag | Bovines/Cattle | Bovines/Cattle CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T43115-Ag | Equine/Horse | Equine/Horse CD45/CD45RA/CD45RO/PTPRC VLP (virus-like particle) | HEK293 | Products Developing |
