Explore TLR1/CD281 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T42932
|
| Target Name |
TLR1/CD281
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7096
|
| Gene ID |
100049577 (Equus caballus), 21897 (Mus musculus), 305354 (Rattus norvegicus), 493660 (Felis catus) 574289 (Macaca mulatta), 7096 (Homo sapiens)
|
| Target Alternative Names |
CD281,TIL,TIL. LPRS5,TLR1,Tlr1,Toll-like receptor 1,Toll/interleukin-1 receptor-like protein (TIL),rsc786
|
| Uniprot Accession |
Q9EPQ1,Q15399
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Toll-like receptor signaling pathway, Tuberculosis
|
| Gene Ensembl |
ENSECAG00000038588, ENSMUSG00000044827, ENSMMUG00000016754, ENSG00000174125
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of TLR1/CD281 cDNA Clones/ORF Plasmid
TLR1/CD281 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7096 | Pre-made Human TLR1/TIL/CD281 siRNA oligo Duplex | 7096 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo305354 | Pre-made Rat Tlr1 siRNA oligo Duplex | 305354 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21897 | Pre-made Mouse Tlr1 siRNA oligo Duplex | 21897 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574289 | Pre-made Cynomolgus/Rhesus macaque TLR1 siRNA oligo Duplex | 574289 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493660 | Pre-made Cat/Feline TLR1 siRNA oligo Duplex | 493660 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100049577 | Pre-made Equine/Horse TLR1 siRNA oligo Duplex | 100049577 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TLR1/CD281 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T42932-Ab | Human | Anti-Human TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T42932-Ab | Rat | Anti-Rat TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T42932-Ab | Mouse | Anti-Mouse TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T42932-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T42932-Ab | Cat/Feline | Anti-Cat/Feline TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T42932-Ab | Equine/Horse | Anti-Equine/Horse TLR1/CD281 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TLR1/CD281 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T42932-Ag | Human | Human TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T42932-Ag | Rat | Rat TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T42932-Ag | Mouse | Mouse TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T42932-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T42932-Ag | Cat/Feline | Cat/Feline TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T42932-Ag | Equine/Horse | Equine/Horse TLR1/CD281 VLP (virus-like particle) | HEK293 | Products Developing |