Cathepsin L/CTSL Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore Cathepsin L/CTSL gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

Target ID	GM-T41141
Target Name	Cathepsin L/CTSL
Gene Group ldentifer （Target Gene ID in Homo species)	1514
Gene ID	100061532 (Equus caballus), 13039 (Mus musculus), 1514 (Homo sapiens), 694569 (Macaca mulatta)
Target Alternative Names	1190035F06Rik,CATL,CTSL,CTSL1,CatL,Cathepsin L,Cathepsin L1,Ctsl,Ctsl1,MEP,Major excreted protein (MEP),Procathepsin L,fs,nkt
Uniprot Accession	P06797,P07711
Protein Sub-location	Transmembrane Protein
Category	Therapeutics Target
Disease	cancer
Disease from KEGG	Lysosome, Phagosome, Apoptosis, Antigen processing and presentation, Proteoglycans in cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis
Gene Ensembl	ENSECAG00000007210, ENSMUSG00000021477, ENSG00000135047, ENSMMUG00000017609
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of Cathepsin L/CTSL cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLP003547	Human CTSL/CATL/CTSL1 Lentivirus plasmid	NM_001257972	1514	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLP003547	Human CTSL/CATL/CTSL1 Lentivirus particle	NM_001257972	1514	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLPm002598	Mouse Ctsl/1190035F06Rik/CatL Lentivirus plasmid	NM_009984	13039	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLPm002598	Mouse Ctsl/1190035F06Rik/CatL Lentivirus particle	NM_009984	13039	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

Cathepsin L/CTSL siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo1514	Pre-made Human CTSL/MEP/CATL siRNA oligo Duplex	1514	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo13039	Pre-made Mouse Ctsl/fs/MEP siRNA oligo Duplex	13039	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo694569	Pre-made Cynomolgus/Rhesus macaque CTSL siRNA oligo Duplex	694569	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo100061532	Pre-made Equine/Horse CTSL siRNA oligo Duplex	100061532	Equine/Horse	In-vitro grade; in-vivo grade	Detail

Cathepsin L/CTSL antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-T41141-Ab	Human	Anti-Human Cathepsin L/CTSL monoclonal antibody	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody	Detail
GM-Tg-mg-T41141-Ab	Mouse	Anti-Mouse Cathepsin L/CTSL monoclonal antibody	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody	Detail
GM-Tg-cynog-T41141-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque Cathepsin L/CTSL monoclonal antibody	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody	Detail
GM-Tg-equg-T41141-Ab	Equine/Horse	Anti-Equine/Horse Cathepsin L/CTSL monoclonal antibody	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody	Detail

Cathepsin L/CTSL VLP (virus-like particle)/protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-T41141-Ag	Human	Human Cathepsin L/CTSL VLP (virus-like particle)	HEK293	Products Developing
GM-Tg-mg-T41141-Ag	Mouse	Mouse Cathepsin L/CTSL VLP (virus-like particle)	HEK293	Products Developing
GM-Tg-cynog-T41141-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque Cathepsin L/CTSL VLP (virus-like particle)	HEK293	Products Developing
GM-Tg-equg-T41141-Ag	Equine/Horse	Equine/Horse Cathepsin L/CTSL VLP (virus-like particle)	HEK293	Products Developing