Explore ATP1A1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
| Target ID |
GM-T40800
|
| Target Name |
ATP1A1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
476
|
| Gene ID |
100034139 (Equus caballus), 101083695 (Felis catus), 11928 (Mus musculus), 24211 (Rattus norvegicus) 282144 (Bos taurus), 403992 (Canis lupus familiaris), 476 (Homo sapiens), 710368 (Macaca mulatta)
|
| Target Alternative Names |
ATP1A1,Atp1a1,Atpa-1,CMT2DD,HOMGSMR2,Na(+)/K(+) ATPase alpha-1 subunit,Nkaa1b,Sodium pump subunit alpha-1,Sodium/potassium-transporting ATPase subunit alpha-1
|
| Uniprot Accession |
P18907,Q8VDN2,P06685,Q08DA1,P50997,P05023
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption
|
| Gene Ensembl |
ENSECAG00000024623, ENSMUSG00000033161, ENSBTAG00000001246, ENSCAFG00845028456, ENSG00000163399, ENSMMUG00000008151
|
Pre-made viral vector of ATP1A1 cDNA Clones/ORF Plasmid
ATP1A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo476 | Pre-made Human ATP1A1/CMT2DD/HOMGSMR2 siRNA oligo Duplex | 476 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24211 | Pre-made Rat Atp1a1/Nkaa1b siRNA oligo Duplex | 24211 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11928 | Pre-made Mouse Atp1a1/Atpa-1 siRNA oligo Duplex | 11928 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710368 | Pre-made Cynomolgus/Rhesus macaque ATP1A1 siRNA oligo Duplex | 710368 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083695 | Pre-made Cat/Feline ATP1A1 siRNA oligo Duplex | 101083695 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403992 | Pre-made Dog/Canine ATP1A1 siRNA oligo Duplex | 403992 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282144 | Pre-made Bovines/Cattle ATP1A1 siRNA oligo Duplex | 282144 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034139 | Pre-made Equine/Horse ATP1A1 siRNA oligo Duplex | 100034139 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATP1A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T40800-Ab | Human | Anti-Human ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T40800-Ab | Rat | Anti-Rat ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T40800-Ab | Mouse | Anti-Mouse ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T40800-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T40800-Ab | Cat/Feline | Anti-Cat/Feline ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T40800-Ab | Dog/Canine | Anti-Dog/Canine ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T40800-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T40800-Ab | Equine/Horse | Anti-Equine/Horse ATP1A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ATP1A1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T40800-Ag | Human | Human ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T40800-Ag | Rat | Rat ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T40800-Ag | Mouse | Mouse ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T40800-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T40800-Ag | Cat/Feline | Cat/Feline ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T40800-Ag | Dog/Canine | Dog/Canine ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T40800-Ag | Bovines/Cattle | Bovines/Cattle ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T40800-Ag | Equine/Horse | Equine/Horse ATP1A1 VLP (virus-like particle) | HEK293 | Products Developing |