Explore MRP4/ABCC4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
| Target ID |
GM-T39919
|
| Target Name |
MRP4/ABCC4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10257
|
| Gene ID |
100050431 (Equus caballus), 101096129 (Felis catus), 10257 (Homo sapiens), 170924 (Rattus norvegicus)
239273 (Mus musculus), 485523 (Canis lupus familiaris), 695407 (Macaca mulatta)
|
| Target Alternative Names |
ABCC4,ABCC4-N1,ATP-binding cassette sub-family C member 4,Abcc4,D630049P08Rik,MOAT-B,MOATB,MRP/cMOAT-related ABC transporter,MRP4,Mrp4,Multi-specific organic anion transporter B (MOAT-B),Multidrug resistance-associated protein 4,RGD1565953
|
| Uniprot Accession |
O15439,F1M3J4,E9Q236
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Antifolate resistance, ABC transporters, cAMP signaling pathway, Bile secretion
|
| Gene Ensembl |
ENSECAG00000017168, ENSG00000125257, ENSMUSG00000032849, ENSCAFG00845008054, ENSMMUG00000021807
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MRP4/ABCC4 cDNA Clones/ORF Plasmid
MRP4/ABCC4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10257 | Pre-made Human ABCC4/MRP4/MOATB siRNA oligo Duplex | 10257 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170924 | Pre-made Rat Abcc4/Mrp4/RGD1565953 siRNA oligo Duplex | 170924 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo239273 | Pre-made Mouse Abcc4/MRP4/MOATB siRNA oligo Duplex | 239273 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695407 | Pre-made Cynomolgus/Rhesus macaque ABCC4 siRNA oligo Duplex | 695407 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096129 | Pre-made Cat/Feline ABCC4 siRNA oligo Duplex | 101096129 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485523 | Pre-made Dog/Canine ABCC4 siRNA oligo Duplex | 485523 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050431 | Pre-made Equine/Horse ABCC4 siRNA oligo Duplex | 100050431 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MRP4/ABCC4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T39919-Ab | Human | Anti-Human MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T39919-Ab | Rat | Anti-Rat MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T39919-Ab | Mouse | Anti-Mouse MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T39919-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T39919-Ab | Cat/Feline | Anti-Cat/Feline MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T39919-Ab | Dog/Canine | Anti-Dog/Canine MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T39919-Ab | Equine/Horse | Anti-Equine/Horse MRP4/ABCC4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MRP4/ABCC4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T39919-Ag | Human | Human MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T39919-Ag | Rat | Rat MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T39919-Ag | Mouse | Mouse MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T39919-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T39919-Ag | Cat/Feline | Cat/Feline MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T39919-Ag | Dog/Canine | Dog/Canine MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T39919-Ag | Equine/Horse | Equine/Horse MRP4/ABCC4 VLP (virus-like particle) | HEK293 | Products Developing |
