Explore SCN5A/Nav1.5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene have been associated with long QT syndrome type 3 (LQT3), atrial fibrillation, cardiomyopathy, and Brugada syndrome 1, all autosomal dominant cardiac diseases. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2022]
| Target ID |
GM-T39716
|
| Target Name |
SCN5A/Nav1.5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6331
|
| Gene ID |
100034027 (Equus caballus), 101100994 (Felis catus), 20271 (Mus musculus), 25665 (Rattus norvegicus)
282061 (Bos taurus), 403497 (Canis lupus familiaris), 6331 (Homo sapiens), 695085 (Macaca mulatta)
|
| Target Alternative Names |
CDCD2,CMD1E,CMPD2,HB1,HB2,HBBD,HH1,ICCD,IVF,LQT3,Nav1.5,Nav1.5c,PFHB1,RATRSKM2X,RSKM2X,SCAL,SCN5A,SSS1,Scn2x,Scn5a,SkM1,SkM2,Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type V subunit alpha,VF1,Voltage-gated sodium channel subunit alpha Nav1.5,hH1,mH1,rSkM2
|
| Uniprot Accession |
Q9JJV9,P15389,Q14524
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Adrenergic signaling in cardiomyocytes
|
| Gene Ensembl |
ENSECAG00000000813, ENSMUSG00000032511, ENSBTAG00000009155, ENSCAFG00845030126, ENSG00000183873, ENSMMUG00000015825
|
| Target Classification |
Ion Channel
|
SCN5A/Nav1.5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6331 | Pre-made Human SCN5A/HB1/HB2 siRNA oligo Duplex | 6331 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25665 | Pre-made Rat Scn5a/SCAL/Scn2x siRNA oligo Duplex | 25665 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20271 | Pre-made Mouse Scn5a/mH1/SkM1 siRNA oligo Duplex | 20271 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695085 | Pre-made Cynomolgus/Rhesus macaque SCN5A siRNA oligo Duplex | 695085 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100994 | Pre-made Cat/Feline SCN5A siRNA oligo Duplex | 101100994 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403497 | Pre-made Dog/Canine SCN5A/Nav1.5 siRNA oligo Duplex | 403497 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282061 | Pre-made Bovines/Cattle SCN5A siRNA oligo Duplex | 282061 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034027 | Pre-made Equine/Horse SCN5A siRNA oligo Duplex | 100034027 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SCN5A/Nav1.5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T39716-Ab | Human | Anti-Human SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T39716-Ab | Rat | Anti-Rat SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T39716-Ab | Mouse | Anti-Mouse SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T39716-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T39716-Ab | Cat/Feline | Anti-Cat/Feline SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T39716-Ab | Dog/Canine | Anti-Dog/Canine SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T39716-Ab | Bovines/Cattle | Anti-Bovines/Cattle SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T39716-Ab | Equine/Horse | Anti-Equine/Horse SCN5A/Nav1.5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SCN5A/Nav1.5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T39716-Ag | Human | Human SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T39716-Ag | Rat | Rat SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T39716-Ag | Mouse | Mouse SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T39716-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T39716-Ag | Cat/Feline | Cat/Feline SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T39716-Ag | Dog/Canine | Dog/Canine SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T39716-Ag | Bovines/Cattle | Bovines/Cattle SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T39716-Ag | Equine/Horse | Equine/Horse SCN5A/Nav1.5 VLP (virus-like particle) | HEK293 | Products Developing |
