Explore NPR2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T37808
|
| Target Name |
NPR2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4882
|
| Gene ID |
100055416 (Equus caballus), 101094301 (Felis catus), 116564 (Rattus norvegicus), 230103 (Mus musculus)
281357 (Bos taurus), 474762 (Canis lupus familiaris), 4882 (Homo sapiens), 695750 (Macaca mulatta)
|
| Target Alternative Names |
NPR2,Npr2,GC-B,NPR-B,cn,pwe,GC-B2,GC-B3,mNPR-B,GCB,AMD1,AMDM,ANPb,ECDM,NPRB,SNSK,ANPRB,GUC2B,NPRBi,GUCY2B
|
| Uniprot Accession |
P16067,Q6VVW5,P46197,P20594
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Metabolic pathways, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Oxytocin signaling pathway
|
| Gene Ensembl |
ENSECAG00000011281, ENSMUSG00000028469, ENSBTAG00000011434, ENSCAFG00845009777, ENSG00000159899, ENSMMUG00000016334
|
| Target Classification |
|
NPR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4882 | Pre-made Human NPR2/GCB/AMD1 siRNA oligo Duplex | 4882 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116564 | Pre-made Rat Npr2/GC-B/NPR-B siRNA oligo Duplex | 116564 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo230103 | Pre-made Mouse Npr2/cn/pwe siRNA oligo Duplex | 230103 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695750 | Pre-made Cynomolgus/Rhesus macaque NPR2 siRNA oligo Duplex | 695750 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094301 | Pre-made Cat/Feline NPR2 siRNA oligo Duplex | 101094301 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474762 | Pre-made Dog/Canine NPR2 siRNA oligo Duplex | 474762 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281357 | Pre-made Bovines/Cattle NPR2 siRNA oligo Duplex | 281357 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055416 | Pre-made Equine/Horse NPR2 siRNA oligo Duplex | 100055416 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NPR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T37808-Ab | Human | Anti-Human NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T37808-Ab | Rat | Anti-Rat NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T37808-Ab | Mouse | Anti-Mouse NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T37808-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T37808-Ab | Cat/Feline | Anti-Cat/Feline NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T37808-Ab | Dog/Canine | Anti-Dog/Canine NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T37808-Ab | Bovines/Cattle | Anti-Bovines/Cattle NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T37808-Ab | Equine/Horse | Anti-Equine/Horse NPR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NPR2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T37808-Ag | Human | Human NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T37808-Ag | Rat | Rat NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T37808-Ag | Mouse | Mouse NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T37808-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T37808-Ag | Cat/Feline | Cat/Feline NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T37808-Ag | Dog/Canine | Dog/Canine NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T37808-Ag | Bovines/Cattle | Bovines/Cattle NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T37808-Ag | Equine/Horse | Equine/Horse NPR2 VLP (virus-like particle) | HEK293 | Products Developing |
