Explore F5 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T37510
|
| Target Name |
F5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2153
|
| Gene ID |
100058503 (Equus caballus), 100685858 (Canis lupus familiaris), 101085264 (Felis catus), 14067 (Mus musculus)
2153 (Homo sapiens), 280687 (Bos taurus), 304929 (Rattus norvegicus), 704695 (Macaca mulatta)
|
| Target Alternative Names |
F5,Cf5,Cf-5,FVL,PCCF,THPH2,RPRGL1,Ac2-120
|
| Uniprot Accession |
O88783,P12259,Q28107
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSECAG00000006860, ENSCAFG00845002341, ENSMUSG00000026579, ENSG00000198734, ENSBTAG00000017722, ENSMMUG00000042510
|
| Target Classification |
|
F5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2153 | Pre-made Human F5/FVL/PCCF siRNA oligo Duplex | 2153 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo304929 | Pre-made Rat F5/Ac2-120 siRNA oligo Duplex | 304929 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14067 | Pre-made Mouse F5/Cf5/Cf-5 siRNA oligo Duplex | 14067 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704695 | Pre-made Cynomolgus/Rhesus macaque F5 siRNA oligo Duplex | 704695 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085264 | Pre-made Cat/Feline F5 siRNA oligo Duplex | 101085264 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100685858 | Pre-made Dog/Canine F5 siRNA oligo Duplex | 100685858 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280687 | Pre-made Bovines/Cattle F5 siRNA oligo Duplex | 280687 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058503 | Pre-made Equine/Horse F5 siRNA oligo Duplex | 100058503 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
F5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T37510-Ab | Human | Anti-Human F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T37510-Ab | Rat | Anti-Rat F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T37510-Ab | Mouse | Anti-Mouse F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T37510-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T37510-Ab | Cat/Feline | Anti-Cat/Feline F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T37510-Ab | Dog/Canine | Anti-Dog/Canine F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T37510-Ab | Bovines/Cattle | Anti-Bovines/Cattle F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T37510-Ab | Equine/Horse | Anti-Equine/Horse F5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
F5 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T37510-Ag | Human | Human F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T37510-Ag | Rat | Rat F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T37510-Ag | Mouse | Mouse F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T37510-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T37510-Ag | Cat/Feline | Cat/Feline F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T37510-Ag | Dog/Canine | Dog/Canine F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T37510-Ag | Bovines/Cattle | Bovines/Cattle F5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T37510-Ag | Equine/Horse | Equine/Horse F5 VLP (virus-like particle) | HEK293 | Products Developing |
