Explore ACVRL1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T36959
|
| Target Name |
ACVRL1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
94
|
| Gene ID |
100061313 (Equus caballus), 101097406 (Felis catus), 11482 (Mus musculus), 25237 (Rattus norvegicus)
477603 (Canis lupus familiaris), 534536 (Bos taurus), 696471 (Macaca mulatta), 94 (Homo sapiens)
|
| Target Alternative Names |
ACVRL1,Acvrl1,HHT,ALK1,HHT2,ORW2,SKR3,ALK-1,TSR-I,ACVRLK1,Alk1,Acvrlk1,R3,R-3,SETHKIR
|
| Uniprot Accession |
Q61288,P80203,P37023
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction
|
| Gene Ensembl |
ENSECAG00000009133, ENSMUSG00000000530, ENSCAFG00845027472, ENSBTAG00000013843, ENSMMUG00000004982, ENSG00000139567
|
| Target Classification |
Cytokine Receptor, Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of ACVRL1 cDNA Clones/ORF Plasmid
ACVRL1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo94 | Pre-made Human ACVRL1/HHT/ALK1 siRNA oligo Duplex | 94 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25237 | Pre-made Rat Acvrl1/R3/R-3 siRNA oligo Duplex | 25237 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11482 | Pre-made Mouse Acvrl1/Alk1/Acvrlk1 siRNA oligo Duplex | 11482 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696471 | Pre-made Cynomolgus/Rhesus macaque ACVRL1 siRNA oligo Duplex | 696471 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097406 | Pre-made Cat/Feline ACVRL1/HHT/ALK1 siRNA oligo Duplex | 101097406 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477603 | Pre-made Dog/Canine ACVRL1 siRNA oligo Duplex | 477603 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534536 | Pre-made Bovines/Cattle ACVRL1 siRNA oligo Duplex | 534536 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061313 | Pre-made Equine/Horse ACVRL1 siRNA oligo Duplex | 100061313 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ACVRL1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T36959-Ab | Human | Anti-Human ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T36959-Ab | Rat | Anti-Rat ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T36959-Ab | Mouse | Anti-Mouse ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T36959-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T36959-Ab | Cat/Feline | Anti-Cat/Feline ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T36959-Ab | Dog/Canine | Anti-Dog/Canine ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T36959-Ab | Bovines/Cattle | Anti-Bovines/Cattle ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T36959-Ab | Equine/Horse | Anti-Equine/Horse ACVRL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
ACVRL1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T36959-Ag | Human | Human ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T36959-Ag | Rat | Rat ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T36959-Ag | Mouse | Mouse ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T36959-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T36959-Ag | Cat/Feline | Cat/Feline ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T36959-Ag | Dog/Canine | Dog/Canine ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T36959-Ag | Bovines/Cattle | Bovines/Cattle ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T36959-Ag | Equine/Horse | Equine/Horse ACVRL1 VLP (virus-like particle) | HEK293 | Products Developing |
