Explore GLP1R gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
| Target ID |
GM-T36075
|
| Target Name |
GLP1R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2740
|
| Gene ID |
100065307 (Equus caballus), 101095495 (Felis catus), 14652 (Mus musculus), 25051 (Rattus norvegicus)
2740 (Homo sapiens), 481778 (Canis lupus familiaris), 517420 (Bos taurus), 719548 (Macaca mulatta)
|
| Target Alternative Names |
GLP-1,GLP-1 receptor,GLP-1-R,GLP-1R,GLP1R,GLP1Rc,Glip,Glp1r,Glucagon-like peptide 1 receptor,RATGL1RCP
|
| Uniprot Accession |
O35659,P32301,P43220
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion
|
| Gene Ensembl |
ENSECAG00000016951, ENSMUSG00000024027, ENSG00000112164, ENSCAFG00845014014, ENSBTAG00000018224, ENSMMUG00000023387
|
| Target Classification |
GPCR
|
Pre-made viral vector of GLP1R cDNA Clones/ORF Plasmid
GLP1R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2740 | Pre-made Human GLP1R/GLP-1/GLP-1R siRNA oligo Duplex | 2740 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25051 | Pre-made Rat Glp1r/Glip/RATGL1RCP siRNA oligo Duplex | 25051 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14652 | Pre-made Mouse Glp1r/GLP-1R/GLP1Rc siRNA oligo Duplex | 14652 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719548 | Pre-made Cynomolgus/Rhesus macaque GLP1R siRNA oligo Duplex | 719548 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095495 | Pre-made Cat/Feline GLP1R siRNA oligo Duplex | 101095495 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481778 | Pre-made Dog/Canine GLP1R siRNA oligo Duplex | 481778 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo517420 | Pre-made Bovines/Cattle GLP1R siRNA oligo Duplex | 517420 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065307 | Pre-made Equine/Horse GLP1R siRNA oligo Duplex | 100065307 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GLP1R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T36075-Ab | Human | Anti-Human GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T36075-Ab | Rat | Anti-Rat GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T36075-Ab | Mouse | Anti-Mouse GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T36075-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T36075-Ab | Cat/Feline | Anti-Cat/Feline GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T36075-Ab | Dog/Canine | Anti-Dog/Canine GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T36075-Ab | Bovines/Cattle | Anti-Bovines/Cattle GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T36075-Ab | Equine/Horse | Anti-Equine/Horse GLP1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GLP1R VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T36075-Ag | Human | Human GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T36075-Ag | Rat | Rat GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T36075-Ag | Mouse | Mouse GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T36075-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T36075-Ag | Cat/Feline | Cat/Feline GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T36075-Ag | Dog/Canine | Dog/Canine GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T36075-Ag | Bovines/Cattle | Bovines/Cattle GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T36075-Ag | Equine/Horse | Equine/Horse GLP1R VLP (virus-like particle) | HEK293 | Products Developing |
