Explore CD11a/Integrin Alpha L/ITGAL gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T35640
|
| Target Name |
CD11a/Integrin Alpha L/ITGAL
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3683
|
| Gene ID |
100065508 (Equus caballus), 101085940 (Felis catus), 16408 (Mus musculus), 281874 (Bos taurus)
308995 (Rattus norvegicus), 3683 (Homo sapiens), 489905 (Canis lupus familiaris), 711945 (Macaca mulatta)
|
| Target Alternative Names |
(p180),CD11 antigen-like family member A,CD11A,CD11a,Cd11a,ITGAL,Integrin Alpha L,Integrin alpha-L,Itgal,LFA-1,LFA-1A,LFA1A,Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A),Leukocyte function-associated molecule 1 alpha chain,Ly-15,Ly-21
|
| Uniprot Accession |
P24063,P61625,P20701
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Rap1 signaling pathway, Cell adhesion molecules, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Malaria, Staphylococcus aureus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis
|
| Gene Ensembl |
ENSECAG00000008485, ENSMUSG00000030830, ENSBTAG00000007103, ENSG00000005844, ENSCAFG00845013917, ENSMMUG00000016876
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD11a/Integrin Alpha L/ITGAL cDNA Clones/ORF Plasmid
CD11a/Integrin Alpha L/ITGAL siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3683 | Pre-made Human ITGAL/CD11A/LFA-1 siRNA oligo Duplex | 3683 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo308995 | Pre-made Rat Itgal/LFA-1 siRNA oligo Duplex | 308995 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16408 | Pre-made Mouse Itgal/Cd11a/LFA-1 siRNA oligo Duplex | 16408 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711945 | Pre-made Cynomolgus/Rhesus macaque ITGAL siRNA oligo Duplex | 711945 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085940 | Pre-made Cat/Feline ITGAL siRNA oligo Duplex | 101085940 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489905 | Pre-made Dog/Canine ITGAL siRNA oligo Duplex | 489905 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281874 | Pre-made Bovines/Cattle ITGAL siRNA oligo Duplex | 281874 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065508 | Pre-made Equine/Horse ITGAL siRNA oligo Duplex | 100065508 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD11a/Integrin Alpha L/ITGAL antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35640-Ab | Human | Anti-Human CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T35640-Ab | Rat | Anti-Rat CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T35640-Ab | Mouse | Anti-Mouse CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T35640-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T35640-Ab | Cat/Feline | Anti-Cat/Feline CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T35640-Ab | Dog/Canine | Anti-Dog/Canine CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T35640-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T35640-Ab | Equine/Horse | Anti-Equine/Horse CD11a/Integrin Alpha L/ITGAL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35640-Ag | Human | Human CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T35640-Ag | Rat | Rat CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T35640-Ag | Mouse | Mouse CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T35640-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T35640-Ag | Cat/Feline | Cat/Feline CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T35640-Ag | Dog/Canine | Dog/Canine CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T35640-Ag | Bovines/Cattle | Bovines/Cattle CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T35640-Ag | Equine/Horse | Equine/Horse CD11a/Integrin Alpha L/ITGAL VLP (virus-like particle) | HEK293 | Products Developing |
