Explore Nectin-4/PVRL4/NECTIN4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
| Target ID |
GM-T35591
|
| Target Name |
Nectin-4/PVRL4/NECTIN4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
81607
|
| Gene ID |
100066309 (Equus caballus), 101092485 (Felis catus), 498281 (Rattus norvegicus), 507718 (Bos taurus) 609931 (Canis lupus familiaris), 71740 (Mus musculus), 719843 (Macaca mulatta), 81607 (Homo sapiens)
|
| Target Alternative Names |
1200017F15Rik,EDSS1,Ig superfamily receptor LNIR,LNIR,NECTIN4,Nectin cell adhesion molecule 4,Nectin-4,Nectin4,PRR4,PVRL4,Poliovirus receptor-related protein 4,Prr4,Pvrl4,RGD1559826,nectin-4
|
| Uniprot Accession |
Q5E9Z9,Q8R007,Q96NY8
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
Breast Cancer, Mucocutaneous lymph node syndrome [Kawasaki]
|
| Disease from KEGG |
Adherens junction
|
| Gene Ensembl |
ENSECAG00000016260, ENSBTAG00000017877, ENSCAFG00845029874, ENSMUSG00000006411, ENSMMUG00000064337, ENSG00000143217
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Nectin-4/PVRL4/NECTIN4 cDNA Clones/ORF Plasmid
Nectin-4/PVRL4/NECTIN4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo81607 | Pre-made Human NECTIN4/LNIR/PRR4 siRNA oligo Duplex | 81607 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo498281 | Pre-made Rat Nectin4/Pvrl4/RGD1559826 siRNA oligo Duplex | 498281 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo71740 | Pre-made Mouse Nectin4/Prr4/Pvrl4 siRNA oligo Duplex | 71740 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719843 | Pre-made Cynomolgus/Rhesus macaque NECTIN4 siRNA oligo Duplex | 719843 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092485 | Pre-made Cat/Feline NECTIN4 siRNA oligo Duplex | 101092485 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609931 | Pre-made Dog/Canine NECTIN4/nectin-4 siRNA oligo Duplex | 609931 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507718 | Pre-made Bovines/Cattle NECTIN4/PVRL4 siRNA oligo Duplex | 507718 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066309 | Pre-made Equine/Horse NECTIN4 siRNA oligo Duplex | 100066309 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Nectin-4/PVRL4/NECTIN4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35591-Ab | Human | Anti-Human Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T35591-Ab | Rat | Anti-Rat Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T35591-Ab | Mouse | Anti-Mouse Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T35591-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T35591-Ab | Cat/Feline | Anti-Cat/Feline Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T35591-Ab | Dog/Canine | Anti-Dog/Canine Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T35591-Ab | Bovines/Cattle | Anti-Bovines/Cattle Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T35591-Ab | Equine/Horse | Anti-Equine/Horse Nectin-4/PVRL4/NECTIN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35591-Ag | Human | Human Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T35591-Ag | Rat | Rat Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T35591-Ag | Mouse | Mouse Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T35591-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T35591-Ag | Cat/Feline | Cat/Feline Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T35591-Ag | Dog/Canine | Dog/Canine Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T35591-Ag | Bovines/Cattle | Bovines/Cattle Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T35591-Ag | Equine/Horse | Equine/Horse Nectin-4/PVRL4/NECTIN4 VLP (virus-like particle) | HEK293 | Products Developing |