Explore PON1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T34562
|
| Target Name |
PON1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5444
|
| Gene ID |
100051896 (Equus caballus), 101091522 (Felis catus), 18979 (Mus musculus), 475234 (Canis lupus familiaris)
523798 (Bos taurus), 5444 (Homo sapiens), 699355 (Macaca mulatta), 84024 (Rattus norvegicus)
|
| Target Alternative Names |
Aromatic esterase 1 (A-esterase 1),ESA,K-45,MVCD5,PON,PON 1,PON1,Pon,Pon1,Serum aryldialkylphosphatase 1,Serum paraoxonase/arylesterase 1
|
| Uniprot Accession |
P52430,P27169,P55159
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Poisoning
|
| Gene Ensembl |
ENSECAG00000000344, ENSMUSG00000002588, ENSCAFG00845020626, ENSBTAG00000015654, ENSG00000005421, ENSMMUG00000008011
|
Pre-made viral vector of PON1 cDNA Clones/ORF Plasmid
PON1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5444 | Pre-made Human PON1/ESA/PON siRNA oligo Duplex | 5444 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84024 | Pre-made Rat Pon1 siRNA oligo Duplex | 84024 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18979 | Pre-made Mouse Pon1/Pon siRNA oligo Duplex | 18979 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699355 | Pre-made Cynomolgus/Rhesus macaque PON1 siRNA oligo Duplex | 699355 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091522 | Pre-made Cat/Feline PON1 siRNA oligo Duplex | 101091522 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475234 | Pre-made Dog/Canine PON1 siRNA oligo Duplex | 475234 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo523798 | Pre-made Bovines/Cattle PON1 siRNA oligo Duplex | 523798 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051896 | Pre-made Equine/Horse PON1 siRNA oligo Duplex | 100051896 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PON1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T34562-Ab | Human | Anti-Human PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T34562-Ab | Rat | Anti-Rat PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T34562-Ab | Mouse | Anti-Mouse PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T34562-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T34562-Ab | Cat/Feline | Anti-Cat/Feline PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T34562-Ab | Dog/Canine | Anti-Dog/Canine PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T34562-Ab | Bovines/Cattle | Anti-Bovines/Cattle PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T34562-Ab | Equine/Horse | Anti-Equine/Horse PON1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PON1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T34562-Ag | Human | Human PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T34562-Ag | Rat | Rat PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T34562-Ag | Mouse | Mouse PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T34562-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T34562-Ag | Cat/Feline | Cat/Feline PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T34562-Ag | Dog/Canine | Dog/Canine PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T34562-Ag | Bovines/Cattle | Bovines/Cattle PON1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T34562-Ag | Equine/Horse | Equine/Horse PON1 recombinant protein | Mammalian cell | Detail |
