Explore CX3CL1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T34405
|
| Target Name |
CX3CL1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6376
|
| Gene ID |
101084670 (Felis catus), 102150350 (Equus caballus), 20312 (Mus musculus), 487265 (Canis lupus familiaris) 517354 (Bos taurus), 574225 (Macaca mulatta), 6376 (Homo sapiens), 89808 (Rattus norvegicus)
|
| Target Alternative Names |
ABCD-3,C-X3-C motif chemokine 1,C3Xkine,CX3C,CX3C membrane-anchored chemokine,CX3CL1,CXC3,CXC3C,Cx3c,Cx3cl1,Cxc3,D8Bwg0439e,FK,Fractalkine,NTN,NTT,Neurotactin,SCYD1,Scyd1,Small-inducible cytokine D1,fractalkine,neurotactin
|
| Uniprot Accession |
O35188,P78423,O55145
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, TNF signaling pathway, Human cytomegalovirus infection
|
| Gene Ensembl |
ENSECAG00000031387, ENSMUSG00000031778, ENSCAFG00845003350, ENSBTAG00000024869, ENSMMUG00000059578, ENSG00000006210
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CX3CL1 cDNA Clones/ORF Plasmid
CX3CL1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6376 | Pre-made Human CX3CL1/NTN/NTT siRNA oligo Duplex | 6376 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo89808 | Pre-made Rat Cx3cl1/Cx3c/Scyd1 siRNA oligo Duplex | 89808 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20312 | Pre-made Mouse Cx3cl1/FK/CX3C siRNA oligo Duplex | 20312 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574225 | Pre-made Cynomolgus/Rhesus macaque CX3CL1 siRNA oligo Duplex | 574225 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084670 | Pre-made Cat/Feline CX3CL1 siRNA oligo Duplex | 101084670 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487265 | Pre-made Dog/Canine CX3CL1 siRNA oligo Duplex | 487265 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo517354 | Pre-made Bovines/Cattle CX3CL1 siRNA oligo Duplex | 517354 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102150350 | Pre-made Equine/Horse CX3CL1 siRNA oligo Duplex | 102150350 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CX3CL1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T34405-Ab | Human | Anti-Human CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T34405-Ab | Rat | Anti-Rat CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T34405-Ab | Mouse | Anti-Mouse CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T34405-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T34405-Ab | Cat/Feline | Anti-Cat/Feline CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T34405-Ab | Dog/Canine | Anti-Dog/Canine CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T34405-Ab | Bovines/Cattle | Anti-Bovines/Cattle CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T34405-Ab | Equine/Horse | Anti-Equine/Horse CX3CL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CX3CL1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T34405-Ag | Human | Human CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T34405-Ag | Rat | Rat CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T34405-Ag | Mouse | Mouse CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T34405-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T34405-Ag | Cat/Feline | Cat/Feline CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T34405-Ag | Dog/Canine | Dog/Canine CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T34405-Ag | Bovines/Cattle | Bovines/Cattle CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T34405-Ag | Equine/Horse | Equine/Horse CX3CL1 VLP (virus-like particle) | HEK293 | Products Developing |