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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T34296
|
| Target Name |
MMP13/MMP-13
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4322
|
| Gene ID |
100009711 (Equus caballus), 171052 (Rattus norvegicus), 17386 (Mus musculus), 281914 (Bos taurus) 403763 (Canis lupus familiaris), 4322 (Homo sapiens), 493679 (Felis catus), 703980 (Macaca mulatta)
|
| Target Alternative Names |
CLG3,Clg,Collagenase 3,MANDP1,MDST,MMP-13,MMP13,Matrix metalloproteinase-13 (MMP-13),Mmp1,Mmp13
|
| Uniprot Accession |
O18927,P23097,P33435,O77656,P45452
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
IL-17 signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action
|
| Gene Ensembl |
ENSECAG00000005506, ENSMUSG00000050578, ENSBTAG00000015059, ENSCAFG00845000761, ENSG00000137745, ENSMMUG00000004253
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MMP13/MMP-13 cDNA Clones/ORF Plasmid
MMP13/MMP-13 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4322 | Pre-made Human MMP13/CLG3/MDST siRNA oligo Duplex | 4322 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171052 | Pre-made Rat Mmp13 siRNA oligo Duplex | 171052 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17386 | Pre-made Mouse Mmp13/Clg/Mmp1 siRNA oligo Duplex | 17386 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703980 | Pre-made Cynomolgus/Rhesus macaque MMP13 siRNA oligo Duplex | 703980 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493679 | Pre-made Cat/Feline MMP13 siRNA oligo Duplex | 493679 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403763 | Pre-made Dog/Canine MMP13 siRNA oligo Duplex | 403763 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281914 | Pre-made Bovines/Cattle MMP13 siRNA oligo Duplex | 281914 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100009711 | Pre-made Equine/Horse MMP13 siRNA oligo Duplex | 100009711 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MMP13/MMP-13 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T34296-Ab | Human | Anti-Human MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T34296-Ab | Rat | Anti-Rat MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T34296-Ab | Mouse | Anti-Mouse MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T34296-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T34296-Ab | Cat/Feline | Anti-Cat/Feline MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T34296-Ab | Dog/Canine | Anti-Dog/Canine MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T34296-Ab | Bovines/Cattle | Anti-Bovines/Cattle MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T34296-Ab | Equine/Horse | Anti-Equine/Horse MMP13/MMP-13 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MMP13/MMP-13 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T34296-Ag | Human | Human MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T34296-Ag | Rat | Rat MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T34296-Ag | Mouse | Mouse MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T34296-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T34296-Ag | Cat/Feline | Cat/Feline MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T34296-Ag | Dog/Canine | Dog/Canine MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T34296-Ag | Bovines/Cattle | Bovines/Cattle MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T34296-Ag | Equine/Horse | Equine/Horse MMP13/MMP-13 recombinant protein | Mammalian cell | Detail |