Explore CYP46A1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T33641
|
| Target Name |
CYP46A1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10858
|
| Gene ID |
100051131 (Equus caballus), 101093112 (Felis catus), 10858 (Homo sapiens), 13116 (Mus musculus)
362782 (Rattus norvegicus), 480432 (Canis lupus familiaris), 506438 (Bos taurus), 705843 (Macaca mulatta)
|
| Target Alternative Names |
CH24H,CP46,CYP46,CYP46A1,Cholesterol 24-hydroxylase,Cholesterol 24-monooxygenase,Cholesterol 24S-hydroxylase,Cyp46,Cyp46a1,Cytochrome P450 46A1
|
| Uniprot Accession |
Q9Y6A2,Q9WVK8
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000007407, ENSG00000036530, ENSMUSG00000021259, ENSCAFG00845004031, ENSBTAG00000035544, ENSMMUG00000000100
|
Pre-made viral vector of CYP46A1 cDNA Clones/ORF Plasmid
CYP46A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10858 | Pre-made Human CYP46A1/CP46/CYP46 siRNA oligo Duplex | 10858 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo362782 | Pre-made Rat Cyp46a1 siRNA oligo Duplex | 362782 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13116 | Pre-made Mouse Cyp46a1/CH24H/Cyp46 siRNA oligo Duplex | 13116 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705843 | Pre-made Cynomolgus/Rhesus macaque CYP46A1 siRNA oligo Duplex | 705843 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093112 | Pre-made Cat/Feline CYP46A1 siRNA oligo Duplex | 101093112 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480432 | Pre-made Dog/Canine CYP46A1 siRNA oligo Duplex | 480432 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506438 | Pre-made Bovines/Cattle CYP46A1 siRNA oligo Duplex | 506438 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051131 | Pre-made Equine/Horse CYP46A1 siRNA oligo Duplex | 100051131 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP46A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T33641-Ab | Human | Anti-Human CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T33641-Ab | Rat | Anti-Rat CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T33641-Ab | Mouse | Anti-Mouse CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T33641-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T33641-Ab | Cat/Feline | Anti-Cat/Feline CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T33641-Ab | Dog/Canine | Anti-Dog/Canine CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T33641-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T33641-Ab | Equine/Horse | Anti-Equine/Horse CYP46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CYP46A1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T33641-Ag | Human | Human CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T33641-Ag | Rat | Rat CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T33641-Ag | Mouse | Mouse CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T33641-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T33641-Ag | Cat/Feline | Cat/Feline CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T33641-Ag | Dog/Canine | Dog/Canine CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T33641-Ag | Bovines/Cattle | Bovines/Cattle CYP46A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T33641-Ag | Equine/Horse | Equine/Horse CYP46A1 recombinant protein | Mammalian cell | Detail |
