Explore EGF gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T33425
|
| Target Name |
EGF
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1950
|
| Gene ID |
106782874 (Equus caballus), 13645 (Mus musculus), 1950 (Homo sapiens), 25313 (Rattus norvegicus)
403657 (Canis lupus familiaris), 493978 (Felis catus), 530315 (Bos taurus), 698619 (Macaca mulatta)
|
| Target Alternative Names |
CEGF,EGF,Egf,HOMG4,Pro-epidermal growth factor,URG
|
| Uniprot Accession |
P01132,P01133,P07522,Q9BEA0,Q95ND4
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, Cytokine Target
|
| Disease |
Nephrotoxicity
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Hepatitis C, Human papillomavirus infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Gastric cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000010741, ENSMUSG00000028017, ENSG00000138798, ENSCAFG00845030111, ENSMMUG00000010043
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of EGF cDNA Clones/ORF Plasmid
EGF siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1950 | Pre-made Human EGF/URG/HOMG4 siRNA oligo Duplex | 1950 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25313 | Pre-made Rat Egf siRNA oligo Duplex | 25313 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13645 | Pre-made Mouse Egf siRNA oligo Duplex | 13645 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698619 | Pre-made Cynomolgus/Rhesus macaque EGF siRNA oligo Duplex | 698619 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493978 | Pre-made Cat/Feline EGF siRNA oligo Duplex | 493978 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403657 | Pre-made Dog/Canine EGF/CEGF siRNA oligo Duplex | 403657 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo530315 | Pre-made Bovines/Cattle EGF siRNA oligo Duplex | 530315 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106782874 | Pre-made Equine/Horse EGF siRNA oligo Duplex | 106782874 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EGF antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T33425-Ab | Human | Anti-Human EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T33425-Ab | Rat | Anti-Rat EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T33425-Ab | Mouse | Anti-Mouse EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T33425-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T33425-Ab | Cat/Feline | Anti-Cat/Feline EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T33425-Ab | Dog/Canine | Anti-Dog/Canine EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T33425-Ab | Bovines/Cattle | Anti-Bovines/Cattle EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T33425-Ab | Equine/Horse | Anti-Equine/Horse EGF monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody | Detail |
EGF VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T33425-Ag | Human | Human EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T33425-Ag | Rat | Rat EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T33425-Ag | Mouse | Mouse EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T33425-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T33425-Ag | Cat/Feline | Cat/Feline EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T33425-Ag | Dog/Canine | Dog/Canine EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T33425-Ag | Bovines/Cattle | Bovines/Cattle EGF VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T33425-Ag | Equine/Horse | Equine/Horse EGF VLP (virus-like particle) | HEK293 | Products Developing |
