Explore HTR2B gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
| Target ID |
GM-T31204
|
| Target Name |
HTR2B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3357
|
| Gene ID |
100057052 (Equus caballus), 101095762 (Felis catus), 15559 (Mus musculus), 29581 (Rattus norvegicus)
3357 (Homo sapiens), 403881 (Canis lupus familiaris), 407135 (Bos taurus), 711808 (Macaca mulatta)
|
| Target Alternative Names |
5-HT(2B),5-HT-2B,5-HT-2F,5-HT2B,5-hydroxytryptamine receptor 2B,5HT2B,5htr2b,HTR2B,Htr2b,Serotonin receptor 2B
|
| Uniprot Accession |
Q02152,P30994,P41595
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels
|
| Gene Ensembl |
ENSECAG00000019412, ENSMUSG00000026228, ENSG00000135914, ENSBTAG00000039772, ENSMMUG00000011773
|
| Target Classification |
GPCR
|
Pre-made viral vector of HTR2B cDNA Clones/ORF Plasmid
HTR2B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3357 | Pre-made Human HTR2B/5-HT2B/5-HT-2B siRNA oligo Duplex | 3357 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29581 | Pre-made Rat Htr2b/5-HT2B/5-HT-2B siRNA oligo Duplex | 29581 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15559 | Pre-made Mouse Htr2b/5-HT2B/5-HT-2B siRNA oligo Duplex | 15559 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711808 | Pre-made Cynomolgus/Rhesus macaque HTR2B siRNA oligo Duplex | 711808 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095762 | Pre-made Cat/Feline HTR2B siRNA oligo Duplex | 101095762 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403881 | Pre-made Dog/Canine HTR2B siRNA oligo Duplex | 403881 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407135 | Pre-made Bovines/Cattle HTR2B/5HT2B/5-HT2B siRNA oligo Duplex | 407135 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057052 | Pre-made Equine/Horse HTR2B siRNA oligo Duplex | 100057052 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HTR2B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T31204-Ab | Human | Anti-Human HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T31204-Ab | Rat | Anti-Rat HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T31204-Ab | Mouse | Anti-Mouse HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T31204-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T31204-Ab | Cat/Feline | Anti-Cat/Feline HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T31204-Ab | Dog/Canine | Anti-Dog/Canine HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T31204-Ab | Bovines/Cattle | Anti-Bovines/Cattle HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T31204-Ab | Equine/Horse | Anti-Equine/Horse HTR2B monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HTR2B VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T31204-Ag | Human | Human HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T31204-Ag | Rat | Rat HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T31204-Ag | Mouse | Mouse HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T31204-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T31204-Ag | Cat/Feline | Cat/Feline HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T31204-Ag | Dog/Canine | Dog/Canine HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T31204-Ag | Bovines/Cattle | Bovines/Cattle HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T31204-Ag | Equine/Horse | Equine/Horse HTR2B VLP (virus-like particle) | HEK293 | Products Developing |
