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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
| Target ID |
GM-T30985
|
| Target Name |
HRH2/H2R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3274
|
| Gene ID |
101084599 (Felis catus), 102149608 (Equus caballus), 15466 (Mus musculus), 25461 (Rattus norvegicus)
3274 (Homo sapiens), 403812 (Canis lupus familiaris), 521257 (Bos taurus), 695226 (Macaca mulatta)
|
| Target Alternative Names |
Gastric receptor I,H2R,HH2R,HRH2,Histamine H2 receptor,Hrh2
|
| Uniprot Accession |
P97292,P25102,P25021,P17124
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion
|
| Gene Ensembl |
ENSECAG00000016581, ENSMUSG00000034987, ENSG00000113749, ENSCAFG00845000310, ENSBTAG00000044071
|
| Target Classification |
GPCR
|
Pre-made viral vector of HRH2/H2R cDNA Clones/ORF Plasmid
HRH2/H2R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3274 | Pre-made Human HRH2/H2R/HH2R siRNA oligo Duplex | 3274 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25461 | Pre-made Rat Hrh2/H2R/HH2R siRNA oligo Duplex | 25461 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15466 | Pre-made Mouse Hrh2/H2R/HH2R siRNA oligo Duplex | 15466 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695226 | Pre-made Cynomolgus/Rhesus macaque HRH2 siRNA oligo Duplex | 695226 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084599 | Pre-made Cat/Feline HRH2 siRNA oligo Duplex | 101084599 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403812 | Pre-made Dog/Canine HRH2/H2R/HH2R siRNA oligo Duplex | 403812 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo521257 | Pre-made Bovines/Cattle HRH2 siRNA oligo Duplex | 521257 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102149608 | Pre-made Equine/Horse HRH2 siRNA oligo Duplex | 102149608 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HRH2/H2R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T30985-Ab | Human | Anti-Human HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T30985-Ab | Rat | Anti-Rat HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T30985-Ab | Mouse | Anti-Mouse HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T30985-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T30985-Ab | Cat/Feline | Anti-Cat/Feline HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T30985-Ab | Dog/Canine | Anti-Dog/Canine HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T30985-Ab | Bovines/Cattle | Anti-Bovines/Cattle HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T30985-Ab | Equine/Horse | Anti-Equine/Horse HRH2/H2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HRH2/H2R VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T30985-Ag | Human | Human HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T30985-Ag | Rat | Rat HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T30985-Ag | Mouse | Mouse HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T30985-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T30985-Ag | Cat/Feline | Cat/Feline HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T30985-Ag | Dog/Canine | Dog/Canine HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T30985-Ag | Bovines/Cattle | Bovines/Cattle HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T30985-Ag | Equine/Horse | Equine/Horse HRH2/H2R VLP (virus-like particle) | HEK293 | Products Developing |
