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Target
sublocation: Transmembrane Protein.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T30846
|
| Target Name |
LILRB4/ILT-3/CD85k
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
11006
|
| Gene ID |
11006 (Homo sapiens), 692336 (Macaca mulatta)
|
| Target Alternative Names |
LILRB4,B4,ILT3,LIR5,CD85K,ILT-3,LIR-5,LILRBC
|
| Uniprot Accession |
Q8NHJ6
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Osteoclast differentiation, B cell receptor signaling pathway
|
| Gene Ensembl |
ENSG00000186818, ENSMMUG00000047009
|
| Target Classification |
|
LILRB4/ILT-3/CD85k siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo11006 | Pre-made Human LILRB4/B4/ILT3 siRNA oligo Duplex | 11006 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692336 | Pre-made Cynomolgus/Rhesus macaque LILRB4/LILRBC siRNA oligo Duplex | 692336 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
LILRB4/ILT-3/CD85k antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T30846-Ab | Human | Anti-Human LILRB4/ILT-3/CD85k monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T30846-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LILRB4/ILT-3/CD85k monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LILRB4/ILT-3/CD85k VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T30846-Ag | Human | Human LILRB4/ILT-3/CD85k VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T30846-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LILRB4/ILT-3/CD85k VLP (virus-like particle) | HEK293 | Products Developing |
