Explore HCN4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T30286
|
| Target Name |
HCN4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10021
|
| Gene ID |
100063001 (Equus caballus), 10021 (Homo sapiens), 101090363 (Felis catus), 330953 (Mus musculus)
448794 (Canis lupus familiaris), 59266 (Rattus norvegicus), 705414 (Macaca mulatta), 785689 (Bos taurus)
|
| Target Alternative Names |
BRGDA8,Bcng3,EIG18,HCN4,Hcn3,Hcn4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,SSS2
|
| Uniprot Accession |
Q9Y3Q4,O70507,Q9JKA7
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cAMP signaling pathway, Taste transduction
|
| Gene Ensembl |
ENSECAG00000018537, ENSG00000138622, ENSMUSG00000032338, ENSCAFG00845027098, ENSMMUG00000016564, ENSBTAG00000017466
|
| Target Classification |
Ion Channel
|
Pre-made viral vector of HCN4 cDNA Clones/ORF Plasmid
HCN4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10021 | Pre-made Human HCN4/SSS2/EIG18 siRNA oligo Duplex | 10021 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo59266 | Pre-made Rat Hcn4 siRNA oligo Duplex | 59266 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo330953 | Pre-made Mouse Hcn4/Hcn3/Bcng3 siRNA oligo Duplex | 330953 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705414 | Pre-made Cynomolgus/Rhesus macaque HCN4 siRNA oligo Duplex | 705414 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090363 | Pre-made Cat/Feline HCN4 siRNA oligo Duplex | 101090363 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo448794 | Pre-made Dog/Canine HCN4 siRNA oligo Duplex | 448794 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo785689 | Pre-made Bovines/Cattle HCN4 siRNA oligo Duplex | 785689 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063001 | Pre-made Equine/Horse HCN4 siRNA oligo Duplex | 100063001 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HCN4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T30286-Ab | Human | Anti-Human HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T30286-Ab | Rat | Anti-Rat HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T30286-Ab | Mouse | Anti-Mouse HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T30286-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T30286-Ab | Cat/Feline | Anti-Cat/Feline HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T30286-Ab | Dog/Canine | Anti-Dog/Canine HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T30286-Ab | Bovines/Cattle | Anti-Bovines/Cattle HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T30286-Ab | Equine/Horse | Anti-Equine/Horse HCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HCN4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T30286-Ag | Human | Human HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T30286-Ag | Rat | Rat HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T30286-Ag | Mouse | Mouse HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T30286-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T30286-Ag | Cat/Feline | Cat/Feline HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T30286-Ag | Dog/Canine | Dog/Canine HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T30286-Ag | Bovines/Cattle | Bovines/Cattle HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T30286-Ag | Equine/Horse | Equine/Horse HCN4 VLP (virus-like particle) | HEK293 | Products Developing |
