Explore NOX4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
| Target ID |
GM-T29741
|
| Target Name |
NOX4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
50507
|
| Gene ID |
100050321 (Equus caballus), 101089891 (Felis catus), 378474 (Bos taurus), 485144 (Canis lupus familiaris)
50490 (Mus musculus), 50507 (Homo sapiens), 705931 (Macaca mulatta), 85431 (Rattus norvegicus)
|
| Target Alternative Names |
KOX,KOX-1,Kidney oxidase-1 (KOX-1),Kidney superoxide-producing NADPH oxidase,NADPH oxidase 4,NOX4,Nox4,RENOX,Renal NAD(P)H-oxidase
|
| Uniprot Accession |
Q9JHI8,Q9NPH5,Q924V1
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000010054, ENSBTAG00000018540, ENSCAFG00845025676, ENSMUSG00000030562, ENSG00000086991, ENSMMUG00000011116
|
Pre-made viral vector of NOX4 cDNA Clones/ORF Plasmid
NOX4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo50507 | Pre-made Human NOX4/KOX/KOX-1 siRNA oligo Duplex | 50507 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo85431 | Pre-made Rat Nox4 siRNA oligo Duplex | 85431 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50490 | Pre-made Mouse Nox4 siRNA oligo Duplex | 50490 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705931 | Pre-made Cynomolgus/Rhesus macaque NOX4 siRNA oligo Duplex | 705931 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089891 | Pre-made Cat/Feline NOX4 siRNA oligo Duplex | 101089891 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485144 | Pre-made Dog/Canine NOX4 siRNA oligo Duplex | 485144 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo378474 | Pre-made Bovines/Cattle NOX4 siRNA oligo Duplex | 378474 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050321 | Pre-made Equine/Horse NOX4 siRNA oligo Duplex | 100050321 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NOX4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T29741-Ab | Human | Anti-Human NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T29741-Ab | Rat | Anti-Rat NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T29741-Ab | Mouse | Anti-Mouse NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T29741-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T29741-Ab | Cat/Feline | Anti-Cat/Feline NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T29741-Ab | Dog/Canine | Anti-Dog/Canine NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T29741-Ab | Bovines/Cattle | Anti-Bovines/Cattle NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T29741-Ab | Equine/Horse | Anti-Equine/Horse NOX4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
NOX4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T29741-Ag | Human | Human NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T29741-Ag | Rat | Rat NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T29741-Ag | Mouse | Mouse NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T29741-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T29741-Ag | Cat/Feline | Cat/Feline NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T29741-Ag | Dog/Canine | Dog/Canine NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T29741-Ag | Bovines/Cattle | Bovines/Cattle NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T29741-Ag | Equine/Horse | Equine/Horse NOX4 VLP (virus-like particle) | HEK293 | Products Developing |
