Explore SCN2A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
| Target ID |
GM-T29678
|
| Target Name |
SCN2A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6326
|
| Gene ID |
110876 (Mus musculus), 24766 (Rattus norvegicus), 539718 (Bos taurus), 6326 (Homo sapiens)
|
| Target Alternative Names |
6430408L10,A230052E19Rik,BFIC3,BFIS3,BFNIS,DEE11,EA9,EIEE11,HBA,HBSC II,HBSCI,HBSCII,NAC2,Na(v)1.2,NachII,Nav1.2,RII/RIIA,RNSCPIIR,SCN,SCN2A,SCN2A1,SCN2A2,Scn2a,Scn2a1,Scn2a2,ScpII,Sodium channel protein brain II subunit alpha,Sodium channel protein type 2 subunit alpha,Sodium channel protein type II subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.2
|
| Uniprot Accession |
B1AWN6,P04775,Q99250
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Taste transduction
|
| Gene Ensembl |
ENSMUSG00000075318, ENSBTAG00000038180, ENSG00000136531
|
| Target Classification |
Ion Channel
|
SCN2A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6326 | Pre-made Human SCN2A/EA9/HBA siRNA oligo Duplex | 6326 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24766 | Pre-made Rat Scn2a/SCN/ScpII siRNA oligo Duplex | 24766 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo110876 | Pre-made Mouse Scn2a/Nav1.2/Scn2a1 siRNA oligo Duplex | 110876 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539718 | Pre-made Bovines/Cattle SCN2A/SCN2A1 siRNA oligo Duplex | 539718 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
SCN2A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T29678-Ab | Human | Anti-Human SCN2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T29678-Ab | Rat | Anti-Rat SCN2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T29678-Ab | Mouse | Anti-Mouse SCN2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T29678-Ab | Bovines/Cattle | Anti-Bovines/Cattle SCN2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SCN2A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T29678-Ag | Human | Human SCN2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T29678-Ag | Rat | Rat SCN2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T29678-Ag | Mouse | Mouse SCN2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T29678-Ag | Bovines/Cattle | Bovines/Cattle SCN2A VLP (virus-like particle) | HEK293 | Products Developing |
