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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T28413
|
| Target Name |
EPHA3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2042
|
| Gene ID |
100054527 (Equus caballus), 101085310 (Felis catus), 13837 (Mus musculus), 2042 (Homo sapiens)
29210 (Rattus norvegicus), 487930 (Canis lupus familiaris), 537951 (Bos taurus), 694583 (Macaca mulatta)
|
| Target Alternative Names |
Cek4,EK4,EPH-like kinase 4 (EK4,EPHA3,ETK,ETK1,End3,Epha3,Ephrin type-A receptor 3,HEK,HEK (Human embryo kinase),HEK4,Hek,Hek4,Mek4,TYRO4,Tyro4,Tyrosine-protein kinase TYRO4,Tyrosine-protein kinase receptor ETK1 (Eph-like tyrosine kinase 1),hEK4)
|
| Uniprot Accession |
P29319,P29320,O08680
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Axon guidance
|
| Gene Ensembl |
ENSECAG00000023211, ENSMUSG00000052504, ENSG00000044524, ENSCAFG00845030500, ENSBTAG00000006811, ENSMMUG00000008242
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology
|
Pre-made viral vector of EPHA3 cDNA Clones/ORF Plasmid
EPHA3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2042 | Pre-made Human EPHA3/EK4/ETK siRNA oligo Duplex | 2042 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29210 | Pre-made Rat Epha3 siRNA oligo Duplex | 29210 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13837 | Pre-made Mouse Epha3/EK4/Hek siRNA oligo Duplex | 13837 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694583 | Pre-made Cynomolgus/Rhesus macaque EPHA3 siRNA oligo Duplex | 694583 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085310 | Pre-made Cat/Feline EPHA3 siRNA oligo Duplex | 101085310 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487930 | Pre-made Dog/Canine EPHA3 siRNA oligo Duplex | 487930 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537951 | Pre-made Bovines/Cattle EPHA3 siRNA oligo Duplex | 537951 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054527 | Pre-made Equine/Horse EPHA3 siRNA oligo Duplex | 100054527 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EPHA3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T28413-Ab | Human | Anti-Human EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T28413-Ab | Rat | Anti-Rat EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T28413-Ab | Mouse | Anti-Mouse EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T28413-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T28413-Ab | Cat/Feline | Anti-Cat/Feline EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T28413-Ab | Dog/Canine | Anti-Dog/Canine EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T28413-Ab | Bovines/Cattle | Anti-Bovines/Cattle EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T28413-Ab | Equine/Horse | Anti-Equine/Horse EPHA3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
EPHA3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T28413-Ag | Human | Human EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T28413-Ag | Rat | Rat EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T28413-Ag | Mouse | Mouse EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T28413-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T28413-Ag | Cat/Feline | Cat/Feline EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T28413-Ag | Dog/Canine | Dog/Canine EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T28413-Ag | Bovines/Cattle | Bovines/Cattle EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T28413-Ag | Equine/Horse | Equine/Horse EPHA3 VLP (virus-like particle) | HEK293 | Products Developing |
