Explore Serotonin transporter/SLC6A4/SERT gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
| Target ID |
GM-T27812
|
| Target Name |
Serotonin transporter/SLC6A4/SERT
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6532
|
| Gene ID |
100033848 (Equus caballus), 101091163 (Felis catus), 15567 (Mus musculus), 25553 (Rattus norvegicus)
282365 (Bos taurus), 491184 (Canis lupus familiaris), 574140 (Macaca mulatta), 6532 (Homo sapiens)
|
| Target Alternative Names |
5-HTT,5-HTTLPR,5HT transporter (5HTT),5HTT,HTT,Htt,OCD1,SERT,SERT1,SLC6A4,Serotonin transporter,Sert,Slc6a4,Sodium-dependent serotonin transporter,Solute carrier family 6 member 4,hSERT
|
| Uniprot Accession |
Q60857,P31652,Q9XT49,Q9MYX0,P31645
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Autistic disorder
|
| Disease from KEGG |
Serotonergic synapse
|
| Gene Ensembl |
ENSECAG00000017112, ENSMUSG00000020838, ENSBTAG00000019349, ENSCAFG00845012358, ENSMMUG00000003515, ENSG00000108576
|
Pre-made viral vector of Serotonin transporter/SLC6A4/SERT cDNA Clones/ORF Plasmid
Serotonin transporter/SLC6A4/SERT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6532 | Pre-made Human SLC6A4/HTT/5HTT siRNA oligo Duplex | 6532 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25553 | Pre-made Rat Slc6a4/SERT siRNA oligo Duplex | 25553 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15567 | Pre-made Mouse Slc6a4/Htt/Sert siRNA oligo Duplex | 15567 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574140 | Pre-made Cynomolgus/Rhesus macaque SLC6A4/SERT/5-HTT siRNA oligo Duplex | 574140 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091163 | Pre-made Cat/Feline SLC6A4 siRNA oligo Duplex | 101091163 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491184 | Pre-made Dog/Canine SLC6A4/5-HTT siRNA oligo Duplex | 491184 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282365 | Pre-made Bovines/Cattle SLC6A4/SERT siRNA oligo Duplex | 282365 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033848 | Pre-made Equine/Horse SLC6A4/5HTT siRNA oligo Duplex | 100033848 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Serotonin transporter/SLC6A4/SERT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T27812-Ab | Human | Anti-Human Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T27812-Ab | Rat | Anti-Rat Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T27812-Ab | Mouse | Anti-Mouse Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T27812-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T27812-Ab | Cat/Feline | Anti-Cat/Feline Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T27812-Ab | Dog/Canine | Anti-Dog/Canine Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T27812-Ab | Bovines/Cattle | Anti-Bovines/Cattle Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T27812-Ab | Equine/Horse | Anti-Equine/Horse Serotonin transporter/SLC6A4/SERT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Serotonin transporter/SLC6A4/SERT VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T27812-Ag | Human | Human Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T27812-Ag | Rat | Rat Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T27812-Ag | Mouse | Mouse Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T27812-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T27812-Ag | Cat/Feline | Cat/Feline Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T27812-Ag | Dog/Canine | Dog/Canine Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T27812-Ag | Bovines/Cattle | Bovines/Cattle Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T27812-Ag | Equine/Horse | Equine/Horse Serotonin transporter/SLC6A4/SERT VLP (virus-like particle) | HEK293 | Products Developing |
