Explore CRK/c-Crk gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T27297
|
| Target Name |
CRK/c-Crk
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1398
|
| Gene ID |
100072356 (Equus caballus), 100684309 (Canis lupus familiaris), 101086100 (Felis catus), 12928 (Mus musculus)
1398 (Homo sapiens), 512841 (Bos taurus), 54245 (Rattus norvegicus), 701185 (Macaca mulatta)
|
| Target Alternative Names |
Adapter molecule crk,CRK,CRKII,Crk,Crk-I,Crk-II,Crk-III,Crk3,CrkII,CrkIII,Crko,Proto-oncogene c-Crk,c-Crk,p38
|
| Uniprot Accession |
Q64010,P46108,Q63768
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Focal adhesion, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Growth hormone synthesis, secretion and action, Yersinia infection, Human cytomegalovirus infection, Pathways in cancer, Renal cell carcinoma, Chronic myeloid leukemia
|
| Gene Ensembl |
ENSECAG00000011550, ENSMUSG00000017776, ENSG00000167193, ENSBTAG00000005665, ENSMMUG00000040390
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CRK/c-Crk cDNA Clones/ORF Plasmid
CRK/c-Crk siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1398 | Pre-made Human CRK/p38/CRKII siRNA oligo Duplex | 1398 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54245 | Pre-made Rat Crk/Crko/CrkII siRNA oligo Duplex | 54245 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12928 | Pre-made Mouse Crk/p38/Crk3 siRNA oligo Duplex | 12928 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701185 | Pre-made Cynomolgus/Rhesus macaque CRK siRNA oligo Duplex | 701185 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086100 | Pre-made Cat/Feline CRK siRNA oligo Duplex | 101086100 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100684309 | Pre-made Dog/Canine CRK siRNA oligo Duplex | 100684309 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512841 | Pre-made Bovines/Cattle CRK siRNA oligo Duplex | 512841 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072356 | Pre-made Equine/Horse CRK siRNA oligo Duplex | 100072356 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CRK/c-Crk antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T27297-Ab | Human | Anti-Human CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T27297-Ab | Rat | Anti-Rat CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T27297-Ab | Mouse | Anti-Mouse CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T27297-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T27297-Ab | Cat/Feline | Anti-Cat/Feline CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T27297-Ab | Dog/Canine | Anti-Dog/Canine CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T27297-Ab | Bovines/Cattle | Anti-Bovines/Cattle CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T27297-Ab | Equine/Horse | Anti-Equine/Horse CRK/c-Crk monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CRK/c-Crk VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T27297-Ag | Human | Human CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T27297-Ag | Rat | Rat CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T27297-Ag | Mouse | Mouse CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T27297-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T27297-Ag | Cat/Feline | Cat/Feline CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T27297-Ag | Dog/Canine | Dog/Canine CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T27297-Ag | Bovines/Cattle | Bovines/Cattle CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T27297-Ag | Equine/Horse | Equine/Horse CRK/c-Crk VLP (virus-like particle) | HEK293 | Products Developing |
