Explore mGluR1/GRM1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
| Target ID |
GM-T27137
|
| Target Name |
mGluR1/GRM1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2911
|
| Gene ID |
100060603 (Equus caballus), 101094104 (Felis catus), 14816 (Mus musculus), 24414 (Rattus norvegicus)
2911 (Homo sapiens), 484024 (Canis lupus familiaris), 540485 (Bos taurus), 698736 (Macaca mulatta)
|
| Target Alternative Names |
4930455H15Rik,GPRC1A,GRM1,Gm10828,Gprc1a,Grm1,MGLU1,MGLUR1,Metabotropic glutamate receptor 1,PPP1R85,SCA44,SCAR13,mGluR1,nmf373,rcw,wobl
|
| Uniprot Accession |
P97772,P23385,Q13255
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Calcium signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Long-term potentiation, Glutamatergic synapse, Taste transduction
|
| Gene Ensembl |
ENSECAG00000023691, ENSMUSG00000019828, ENSG00000152822, ENSCAFG00845013661, ENSBTAG00000044181, ENSMMUG00000016428
|
| Target Classification |
GPCR
|
mGluR1/GRM1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2911 | Pre-made Human GRM1/MGLU1/SCA44 siRNA oligo Duplex | 2911 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24414 | Pre-made Rat Grm1/Gprc1a siRNA oligo Duplex | 24414 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14816 | Pre-made Mouse Grm1/rcw/wobl siRNA oligo Duplex | 14816 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698736 | Pre-made Cynomolgus/Rhesus macaque GRM1 siRNA oligo Duplex | 698736 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094104 | Pre-made Cat/Feline GRM1 siRNA oligo Duplex | 101094104 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484024 | Pre-made Dog/Canine GRM1 siRNA oligo Duplex | 484024 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540485 | Pre-made Bovines/Cattle GRM1 siRNA oligo Duplex | 540485 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060603 | Pre-made Equine/Horse GRM1 siRNA oligo Duplex | 100060603 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
mGluR1/GRM1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T27137-Ab | Human | Anti-Human mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T27137-Ab | Rat | Anti-Rat mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T27137-Ab | Mouse | Anti-Mouse mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T27137-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T27137-Ab | Cat/Feline | Anti-Cat/Feline mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T27137-Ab | Dog/Canine | Anti-Dog/Canine mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T27137-Ab | Bovines/Cattle | Anti-Bovines/Cattle mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T27137-Ab | Equine/Horse | Anti-Equine/Horse mGluR1/GRM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
mGluR1/GRM1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T27137-Ag | Human | Human mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T27137-Ag | Rat | Rat mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T27137-Ag | Mouse | Mouse mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T27137-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T27137-Ag | Cat/Feline | Cat/Feline mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T27137-Ag | Dog/Canine | Dog/Canine mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T27137-Ag | Bovines/Cattle | Bovines/Cattle mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T27137-Ag | Equine/Horse | Equine/Horse mGluR1/GRM1 VLP (virus-like particle) | HEK293 | Products Developing |
