Explore TP53BP1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T26983
|
| Target Name |
TP53BP1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7158
|
| Gene ID |
100056322 (Equus caballus), 101098873 (Felis catus), 27223 (Mus musculus), 296099 (Rattus norvegicus) 478274 (Canis lupus familiaris), 509111 (Bos taurus), 710237 (Macaca mulatta), 7158 (Homo sapiens)
|
| Target Alternative Names |
53BP1,TDRD30,TP53-binding protein 1,TP53BP1,Tp53bp1,Trp53bp1,m53BP1,p202,p53-binding protein 1,p53BP1
|
| Uniprot Accession |
P70399,Q12888
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
NOD-like receptor signaling pathway
|
| Gene Ensembl |
ENSECAG00000008093, ENSMUSG00000043909, ENSCAFG00845023383, ENSBTAG00000021304, ENSMMUG00000017078, ENSG00000067369
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of TP53BP1 cDNA Clones/ORF Plasmid
TP53BP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7158 | Pre-made Human TP53BP1/p202/53BP1 siRNA oligo Duplex | 7158 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo296099 | Pre-made Rat Tp53bp1/Trp53bp1 siRNA oligo Duplex | 296099 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo27223 | Pre-made Mouse Trp53bp1/53BP1/m53BP1 siRNA oligo Duplex | 27223 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710237 | Pre-made Cynomolgus/Rhesus macaque TP53BP1 siRNA oligo Duplex | 710237 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098873 | Pre-made Cat/Feline TP53BP1 siRNA oligo Duplex | 101098873 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478274 | Pre-made Dog/Canine TP53BP1 siRNA oligo Duplex | 478274 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509111 | Pre-made Bovines/Cattle TP53BP1 siRNA oligo Duplex | 509111 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056322 | Pre-made Equine/Horse TP53BP1 siRNA oligo Duplex | 100056322 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TP53BP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T26983-Ab | Human | Anti-Human TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T26983-Ab | Rat | Anti-Rat TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T26983-Ab | Mouse | Anti-Mouse TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T26983-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T26983-Ab | Cat/Feline | Anti-Cat/Feline TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T26983-Ab | Dog/Canine | Anti-Dog/Canine TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T26983-Ab | Bovines/Cattle | Anti-Bovines/Cattle TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T26983-Ab | Equine/Horse | Anti-Equine/Horse TP53BP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TP53BP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T26983-Ag | Human | Human TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T26983-Ag | Rat | Rat TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T26983-Ag | Mouse | Mouse TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T26983-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T26983-Ag | Cat/Feline | Cat/Feline TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T26983-Ag | Dog/Canine | Dog/Canine TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T26983-Ag | Bovines/Cattle | Bovines/Cattle TP53BP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T26983-Ag | Equine/Horse | Equine/Horse TP53BP1 recombinant protein | Mammalian cell | Detail |