Explore C3/C3b/C3c/CO3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
| Target ID |
GM-T26851
|
| Target Name |
C3/C3b/C3c/CO3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
718
|
| Gene ID |
12266 (Mus musculus), 24232 (Rattus norvegicus), 280677 (Bos taurus), 476728 (Canis lupus familiaris)
703613 (Macaca mulatta), 718 (Homo sapiens)
|
| Target Alternative Names |
AHUS5,ARMD9,ASP,C3,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1,C3a,C3b,C3c,CO3,CPAMD1,Complement C3,HEL-S-62p,HSE-MSF,Plp
|
| Uniprot Accession |
P01027,P01026,Q2UVX4,P01024
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
Ovary Cancer, Diabetes type-2, Alzheimer's Disease, renal carcinoma
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Alcoholic liver disease, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection
|
| Gene Ensembl |
ENSMUSG00000024164, ENSBTAG00000017280, ENSCAFG00845010104, ENSMMUG00000008693, ENSG00000125730
|
C3/C3b/C3c/CO3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo718 | Pre-made Human C3/ASP/C3a siRNA oligo Duplex | 718 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24232 | Pre-made Rat C3 siRNA oligo Duplex | 24232 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12266 | Pre-made Mouse C3/ASP/Plp siRNA oligo Duplex | 12266 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703613 | Pre-made Cynomolgus/Rhesus macaque C3 siRNA oligo Duplex | 703613 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476728 | Pre-made Dog/Canine C3 siRNA oligo Duplex | 476728 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280677 | Pre-made Bovines/Cattle C3 siRNA oligo Duplex | 280677 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
C3/C3b/C3c/CO3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T26851-Ab | Human | Anti-Human C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T26851-Ab | Rat | Anti-Rat C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T26851-Ab | Mouse | Anti-Mouse C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T26851-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T26851-Ab | Dog/Canine | Anti-Dog/Canine C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T26851-Ab | Bovines/Cattle | Anti-Bovines/Cattle C3/C3b/C3c/CO3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
C3/C3b/C3c/CO3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T26851-Ag | Human | Human C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T26851-Ag | Rat | Rat C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T26851-Ag | Mouse | Mouse C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T26851-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T26851-Ag | Dog/Canine | Dog/Canine C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T26851-Ag | Bovines/Cattle | Bovines/Cattle C3/C3b/C3c/CO3 VLP (virus-like particle) | HEK293 | Products Developing |
